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Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease

Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchronization through...

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Autores principales: Heinrichs-Graham, Elizabeth, Wilson, Tony W., Santamaria, Pamela M., Heithoff, Sheila K., Torres-Russotto, Diego, Hutter-Saunders, Jessica A.L., Estes, Katherine A., Meza, Jane L., Mosley, R. L., Gendelman, Howard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153806/
https://www.ncbi.nlm.nih.gov/pubmed/23645717
http://dx.doi.org/10.1093/cercor/bht121
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author Heinrichs-Graham, Elizabeth
Wilson, Tony W.
Santamaria, Pamela M.
Heithoff, Sheila K.
Torres-Russotto, Diego
Hutter-Saunders, Jessica A.L.
Estes, Katherine A.
Meza, Jane L.
Mosley, R. L.
Gendelman, Howard E.
author_facet Heinrichs-Graham, Elizabeth
Wilson, Tony W.
Santamaria, Pamela M.
Heithoff, Sheila K.
Torres-Russotto, Diego
Hutter-Saunders, Jessica A.L.
Estes, Katherine A.
Meza, Jane L.
Mosley, R. L.
Gendelman, Howard E.
author_sort Heinrichs-Graham, Elizabeth
collection PubMed
description Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchronization throughout the cortical–basal ganglia motor network in PD. Suppression of such pathological beta synchronization has been associated with improved motor function, which may explain the effectiveness of deep-brain stimulation. We used magnetoencephalography (MEG) to investigate neural population-level beta responses, and other oscillatory activity, during a motor task in unmedicated patients with PD and a matched group of healthy adults. MEG is a noninvasive neurophysiological technique that permits the recording of oscillatory activity during movement planning, execution, and termination phases. Each of these phases was independently examined using beamforming to distinguish the brain areas and movement phases, where pathological oscillations exist during motor control. Patients with PD exhibited significantly diminished beta desynchronization compared with controls prior to and during movement, which paralleled reduced alpha desynchronization. This study is the first to systematically investigate neural oscillatory responses in PD during distinct stages of motor control (e.g. planning, execution, and termination) and indicates that these patients have significant difficulty suppressing cortical beta synchronization during movement planning, which may contribute to their diminished movement capacities.
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spelling pubmed-41538062014-09-04 Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease Heinrichs-Graham, Elizabeth Wilson, Tony W. Santamaria, Pamela M. Heithoff, Sheila K. Torres-Russotto, Diego Hutter-Saunders, Jessica A.L. Estes, Katherine A. Meza, Jane L. Mosley, R. L. Gendelman, Howard E. Cereb Cortex Articles Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchronization throughout the cortical–basal ganglia motor network in PD. Suppression of such pathological beta synchronization has been associated with improved motor function, which may explain the effectiveness of deep-brain stimulation. We used magnetoencephalography (MEG) to investigate neural population-level beta responses, and other oscillatory activity, during a motor task in unmedicated patients with PD and a matched group of healthy adults. MEG is a noninvasive neurophysiological technique that permits the recording of oscillatory activity during movement planning, execution, and termination phases. Each of these phases was independently examined using beamforming to distinguish the brain areas and movement phases, where pathological oscillations exist during motor control. Patients with PD exhibited significantly diminished beta desynchronization compared with controls prior to and during movement, which paralleled reduced alpha desynchronization. This study is the first to systematically investigate neural oscillatory responses in PD during distinct stages of motor control (e.g. planning, execution, and termination) and indicates that these patients have significant difficulty suppressing cortical beta synchronization during movement planning, which may contribute to their diminished movement capacities. Oxford University Press 2014-10 2013-05-03 /pmc/articles/PMC4153806/ /pubmed/23645717 http://dx.doi.org/10.1093/cercor/bht121 Text en © The Author 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Articles
Heinrichs-Graham, Elizabeth
Wilson, Tony W.
Santamaria, Pamela M.
Heithoff, Sheila K.
Torres-Russotto, Diego
Hutter-Saunders, Jessica A.L.
Estes, Katherine A.
Meza, Jane L.
Mosley, R. L.
Gendelman, Howard E.
Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease
title Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease
title_full Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease
title_fullStr Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease
title_full_unstemmed Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease
title_short Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease
title_sort neuromagnetic evidence of abnormal movement-related beta desynchronization in parkinson's disease
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153806/
https://www.ncbi.nlm.nih.gov/pubmed/23645717
http://dx.doi.org/10.1093/cercor/bht121
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