TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

OBJECTIVE: Loss of function mutations in PINK1 typically lead to early onset Parkinson disease (PD). Zebrafish (Danio rerio) are emerging as a powerful new vertebrate model to study neurodegenerative diseases. We used a pink1 mutant (pink(−/−)) zebrafish line with a premature stop mutation (Y431*) i...

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Detalles Bibliográficos
Autores principales: Flinn, Laura J., Keatinge, Marcus, Bretaud, Sandrine, Mortiboys, Heather, Matsui, Hideaki, De Felice, Elena, Woodroof, Helen I., Brown, Lucy, McTighe, Aimee, Soellner, Rosemarie, Allen, Claire E., Heath, Paul R., Milo, Marta, Muqit, Miratul M. K., Reichert, Andreas S., Köster, Reinhard W., Ingham, Philip W., Bandmann, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-Liss 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154126/
https://www.ncbi.nlm.nih.gov/pubmed/24027110
http://dx.doi.org/10.1002/ana.23999

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