Acrolein-Exposed Normal Human Lung Fibroblasts in Vitro: Cellular Senescence, Enhanced Telomere Erosion, and Degradation of Werner’s Syndrome Protein

Background: Acrolein is a ubiquitous environmental hazard to human health. Acrolein has been reported to activate the DNA damage response and induce apoptosis. However, little is known about the effects of acrolein on cellular senescence. Objectives: We examined whether acrolein induces cellular sen...

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Detalles Bibliográficos
Autores principales: Jang, Jun-Ho, Bruse, Shannon, Huneidi, Salam, Schrader, Ronald M., Monick, Martha M., Lin, Yong, Carter, A. Brent, Klingelhutz, Aloysius J., Nyunoya, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: NLM-Export 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154210/
https://www.ncbi.nlm.nih.gov/pubmed/24747221
http://dx.doi.org/10.1289/ehp.1306911

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