Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells

Gap junction channels (GJCs) and hemichannels (HCs) are composed of protein subunits termed connexins (Cxs) and are permeable to ions and small molecules. In most organs, GJCs communicate the cytoplasm of adjacent cells, while HCs communicate the intra and extracellular compartments. In this way, bo...

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Detalles Bibliográficos
Autores principales: Figueroa, Vania A., Retamal, Mauricio A., Cea, Luis A., Salas, José D., Vargas, Aníbal A., Verdugo, Christian A., Jara, Oscar, Martínez, Agustín D., Sáez, Juan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154469/
https://www.ncbi.nlm.nih.gov/pubmed/25237294
http://dx.doi.org/10.3389/fncel.2014.00265

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