Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors

BACKGROUND: One of the most provocative recent observations in cancer epigenetics is the discovery of large hypomethylated blocks, including single copy genes, in colorectal cancer, that correspond in location to heterochromatic LOCKs (large organized chromatin lysine-modifications) and LADs (lamin-...

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Detalles Bibliográficos
Autores principales: Timp, Winston, Bravo, Hector Corrada, McDonald, Oliver G, Goggins, Michael, Umbricht, Chris, Zeiger, Martha, Feinberg, Andrew P, Irizarry, Rafael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154522/
https://www.ncbi.nlm.nih.gov/pubmed/25191524
http://dx.doi.org/10.1186/s13073-014-0061-y

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