In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters

Due to the many beneficial properties combined from both poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) and liposomes, lipid-PLGA hybrid NPs have been intensively studied as cancer drug delivery systems, bio-imaging agent carriers, as well as antigen delivery vehicles. However, the impact...

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Detalles Bibliográficos
Autores principales: Hu, Yun, Ehrich, Marion, Fuhrman, Kristel, Zhang, Chenming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154617/
https://www.ncbi.nlm.nih.gov/pubmed/25232295
http://dx.doi.org/10.1186/1556-276X-9-434
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author Hu, Yun
Ehrich, Marion
Fuhrman, Kristel
Zhang, Chenming
author_facet Hu, Yun
Ehrich, Marion
Fuhrman, Kristel
Zhang, Chenming
author_sort Hu, Yun
collection PubMed
description Due to the many beneficial properties combined from both poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) and liposomes, lipid-PLGA hybrid NPs have been intensively studied as cancer drug delivery systems, bio-imaging agent carriers, as well as antigen delivery vehicles. However, the impact of lipid composition on the performance of lipid-PLGA hybrid NPs as a delivery system has not been well investigated. In this study, the influence of lipid composition on the stability of the hybrid NPs and in vitro antigen release from NPs under different conditions was examined. The uptake of hybrid NPs with various surface charges by dendritic cells (DCs) was carefully studied. The results showed that PLGA NPs enveloped by a lipid shell with more positive surface charges could improve the stability of the hybrid NPs, enable better controlled release of antigens encapsulated in PLGA NPs, as well as enhance uptake of NPs by DC.
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spelling pubmed-41546172014-09-17 In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters Hu, Yun Ehrich, Marion Fuhrman, Kristel Zhang, Chenming Nanoscale Res Lett Nano Express Due to the many beneficial properties combined from both poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) and liposomes, lipid-PLGA hybrid NPs have been intensively studied as cancer drug delivery systems, bio-imaging agent carriers, as well as antigen delivery vehicles. However, the impact of lipid composition on the performance of lipid-PLGA hybrid NPs as a delivery system has not been well investigated. In this study, the influence of lipid composition on the stability of the hybrid NPs and in vitro antigen release from NPs under different conditions was examined. The uptake of hybrid NPs with various surface charges by dendritic cells (DCs) was carefully studied. The results showed that PLGA NPs enveloped by a lipid shell with more positive surface charges could improve the stability of the hybrid NPs, enable better controlled release of antigens encapsulated in PLGA NPs, as well as enhance uptake of NPs by DC. Springer 2014-08-27 /pmc/articles/PMC4154617/ /pubmed/25232295 http://dx.doi.org/10.1186/1556-276X-9-434 Text en Copyright © 2014 Hu et al.; licensee Springer. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Nano Express
Hu, Yun
Ehrich, Marion
Fuhrman, Kristel
Zhang, Chenming
In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters
title In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters
title_full In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters
title_fullStr In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters
title_full_unstemmed In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters
title_short In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters
title_sort in vitro performance of lipid-plga hybrid nanoparticles as an antigen delivery system: lipid composition matters
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154617/
https://www.ncbi.nlm.nih.gov/pubmed/25232295
http://dx.doi.org/10.1186/1556-276X-9-434
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