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A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes

Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological functions. The process is catalyzed by myristoyl-C...

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Detalles Bibliográficos
Autores principales:	Galvin, Brendan D., Li, Zhiru, Villemaine, Estelle, Poole, Catherine B., Chapman, Melissa S., Pollastri, Michael P., Wyatt, Paul G., Carlow, Clotilde K. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154664/ https://www.ncbi.nlm.nih.gov/pubmed/25188325 http://dx.doi.org/10.1371/journal.pntd.0003145

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