The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts

Activation of interstitial myofibroblasts and excessive production of extracellular matrix proteins are common pathways that contribute to chronic kidney disease. In a number of tissues, AMP-activated kinase (AMPK) activation has been shown to inhibit fibrosis. Here, we examined the inhibitory effec...

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Detalles Bibliográficos
Autores principales: Chen, Kuan-Hsing, Hsu, Hsiang-Hao, Lee, Cheng-Chia, Yen, Tzu-Hai, Ko, Yi-Ching, Yang, Chih-Wei, Hung, Cheng-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154690/
https://www.ncbi.nlm.nih.gov/pubmed/25188319
http://dx.doi.org/10.1371/journal.pone.0106554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154690/
https://www.ncbi.nlm.nih.gov/pubmed/25188319
http://dx.doi.org/10.1371/journal.pone.0106554

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