Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood – An Observational Study

OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood. METHODS: A total of 57 pregnant women at a gestational age of weeks 11–14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and s...

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Autores principales: Schlütter, Jacob Mørup, Kirkegaard, Ida, Petersen, Olav Bjørn, Larsen, Nanna, Christensen, Britta, Hougaard, David M., Kølvraa, Steen, Uldbjerg, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154776/
https://www.ncbi.nlm.nih.gov/pubmed/25188498
http://dx.doi.org/10.1371/journal.pone.0106934
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author Schlütter, Jacob Mørup
Kirkegaard, Ida
Petersen, Olav Bjørn
Larsen, Nanna
Christensen, Britta
Hougaard, David M.
Kølvraa, Steen
Uldbjerg, Niels
author_facet Schlütter, Jacob Mørup
Kirkegaard, Ida
Petersen, Olav Bjørn
Larsen, Nanna
Christensen, Britta
Hougaard, David M.
Kølvraa, Steen
Uldbjerg, Niels
author_sort Schlütter, Jacob Mørup
collection PubMed
description OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood. METHODS: A total of 57 pregnant women at a gestational age of weeks 11–14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification. RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood. CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.
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spelling pubmed-41547762014-09-08 Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood – An Observational Study Schlütter, Jacob Mørup Kirkegaard, Ida Petersen, Olav Bjørn Larsen, Nanna Christensen, Britta Hougaard, David M. Kølvraa, Steen Uldbjerg, Niels PLoS One Research Article OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood. METHODS: A total of 57 pregnant women at a gestational age of weeks 11–14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification. RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood. CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender. Public Library of Science 2014-09-04 /pmc/articles/PMC4154776/ /pubmed/25188498 http://dx.doi.org/10.1371/journal.pone.0106934 Text en © 2014 Schlütter et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Schlütter, Jacob Mørup
Kirkegaard, Ida
Petersen, Olav Bjørn
Larsen, Nanna
Christensen, Britta
Hougaard, David M.
Kølvraa, Steen
Uldbjerg, Niels
Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood – An Observational Study
title Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood – An Observational Study
title_full Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood – An Observational Study
title_fullStr Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood – An Observational Study
title_full_unstemmed Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood – An Observational Study
title_short Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood – An Observational Study
title_sort fetal gender and several cytokines are associated with the number of fetal cells in maternal blood – an observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154776/
https://www.ncbi.nlm.nih.gov/pubmed/25188498
http://dx.doi.org/10.1371/journal.pone.0106934
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