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A Naturally Occurring Lgr4 Splice Variant Encodes a Soluble Antagonist Useful for Demonstrating the Gonadal Roles of Lgr4 in Mammals
Leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) promotes the Wnt signaling through interaction with R-spondins or norrin. Using PCR amplification from rat ovarian cDNAs, we identified a naturally occurring Lgr4 splice variant encoding only the ectodomain of Lgr4, which was named L...
Autores principales: | Hsu, Pei-Jen, Wu, Fang-Ju, Kudo, Masataka, Hsiao, Chih-Lun, Hsueh, Aaron J. W., Luo, Ching-Wei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154783/ https://www.ncbi.nlm.nih.gov/pubmed/25188337 http://dx.doi.org/10.1371/journal.pone.0106804 |
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