Bacillus Calmette-Guerin Infection in NADPH Oxidase Deficiency: Defective Mycobacterial Sequestration and Granuloma Formation

Patients with chronic granulomatous disease (CGD) lack generation of reactive oxygen species (ROS) through the phagocyte NADPH oxidase NOX2. CGD is an immune deficiency that leads to frequent infections with certain pathogens; this is well documented for S. aureus and A. fumigatus, but less clear fo...

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Detalles Bibliográficos
Autores principales: Deffert, Christine, Schäppi, Michela G., Pache, Jean-Claude, Cachat, Julien, Vesin, Dominique, Bisig, Ruth, Ma Mulone, Xiaojuan, Kelkka, Tiina, Holmdahl, Rikard, Garcia, Irene, Olleros, Maria L., Krause, Karl-Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154868/
https://www.ncbi.nlm.nih.gov/pubmed/25188296
http://dx.doi.org/10.1371/journal.ppat.1004325

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