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Normal Motor Adaptation in Cervical Dystonia: A Fundamental Cerebellar Computation is Intact

The potential role of the cerebellum in the pathophysiology of dystonia has become a focus of recent research. However, direct evidence for a cerebellar contribution in humans with dystonia is difficult to obtain. We examined motor adaptation, a test of cerebellar function, in 20 subjects with prima...

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Autores principales: Sadnicka, Anna, Patani, Bansi, Saifee, Tabish A., Kassavetis, Panagiotis, Pareés, Isabel, Korlipara, Prasad, Bhatia, Kailash P., Rothwell, John C., Galea, Joseph M., Edwards, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155166/
https://www.ncbi.nlm.nih.gov/pubmed/24872202
http://dx.doi.org/10.1007/s12311-014-0569-0
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author Sadnicka, Anna
Patani, Bansi
Saifee, Tabish A.
Kassavetis, Panagiotis
Pareés, Isabel
Korlipara, Prasad
Bhatia, Kailash P.
Rothwell, John C.
Galea, Joseph M.
Edwards, Mark J.
author_facet Sadnicka, Anna
Patani, Bansi
Saifee, Tabish A.
Kassavetis, Panagiotis
Pareés, Isabel
Korlipara, Prasad
Bhatia, Kailash P.
Rothwell, John C.
Galea, Joseph M.
Edwards, Mark J.
author_sort Sadnicka, Anna
collection PubMed
description The potential role of the cerebellum in the pathophysiology of dystonia has become a focus of recent research. However, direct evidence for a cerebellar contribution in humans with dystonia is difficult to obtain. We examined motor adaptation, a test of cerebellar function, in 20 subjects with primary cervical dystonia and an equal number of aged matched controls. Adaptation to both visuomotor (distorting visual feedback by 30°) and forcefield (applying a velocity-dependent force) conditions were tested. Our hypothesis was that cerebellar abnormalities observed in dystonia research would translate into deficits of cerebellar adaptation. We also examined the relationship between adaptation and dystonic head tremor as many primary tremor models implicate the cerebellothalamocortical network which is specifically tested by this motor paradigm. Rates of adaptation (learning) in cervical dystonia were identical to healthy controls in both visuomotor and forcefield tasks. Furthermore, the ability to adapt was not clearly related to clinical features of dystonic head tremor. We have shown that a key motor control function of the cerebellum is intact in the most common form of primary dystonia. These results have important implications for current anatomical models of the pathophysiology of dystonia. It is important to attempt to progress from general statements that implicate the cerebellum to a more specific evidence-based model. The role of the cerebellum in this enigmatic disease perhaps remains to be proven.
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spelling pubmed-41551662014-09-08 Normal Motor Adaptation in Cervical Dystonia: A Fundamental Cerebellar Computation is Intact Sadnicka, Anna Patani, Bansi Saifee, Tabish A. Kassavetis, Panagiotis Pareés, Isabel Korlipara, Prasad Bhatia, Kailash P. Rothwell, John C. Galea, Joseph M. Edwards, Mark J. Cerebellum Original Paper The potential role of the cerebellum in the pathophysiology of dystonia has become a focus of recent research. However, direct evidence for a cerebellar contribution in humans with dystonia is difficult to obtain. We examined motor adaptation, a test of cerebellar function, in 20 subjects with primary cervical dystonia and an equal number of aged matched controls. Adaptation to both visuomotor (distorting visual feedback by 30°) and forcefield (applying a velocity-dependent force) conditions were tested. Our hypothesis was that cerebellar abnormalities observed in dystonia research would translate into deficits of cerebellar adaptation. We also examined the relationship between adaptation and dystonic head tremor as many primary tremor models implicate the cerebellothalamocortical network which is specifically tested by this motor paradigm. Rates of adaptation (learning) in cervical dystonia were identical to healthy controls in both visuomotor and forcefield tasks. Furthermore, the ability to adapt was not clearly related to clinical features of dystonic head tremor. We have shown that a key motor control function of the cerebellum is intact in the most common form of primary dystonia. These results have important implications for current anatomical models of the pathophysiology of dystonia. It is important to attempt to progress from general statements that implicate the cerebellum to a more specific evidence-based model. The role of the cerebellum in this enigmatic disease perhaps remains to be proven. Springer US 2014-05-29 2014 /pmc/articles/PMC4155166/ /pubmed/24872202 http://dx.doi.org/10.1007/s12311-014-0569-0 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Sadnicka, Anna
Patani, Bansi
Saifee, Tabish A.
Kassavetis, Panagiotis
Pareés, Isabel
Korlipara, Prasad
Bhatia, Kailash P.
Rothwell, John C.
Galea, Joseph M.
Edwards, Mark J.
Normal Motor Adaptation in Cervical Dystonia: A Fundamental Cerebellar Computation is Intact
title Normal Motor Adaptation in Cervical Dystonia: A Fundamental Cerebellar Computation is Intact
title_full Normal Motor Adaptation in Cervical Dystonia: A Fundamental Cerebellar Computation is Intact
title_fullStr Normal Motor Adaptation in Cervical Dystonia: A Fundamental Cerebellar Computation is Intact
title_full_unstemmed Normal Motor Adaptation in Cervical Dystonia: A Fundamental Cerebellar Computation is Intact
title_short Normal Motor Adaptation in Cervical Dystonia: A Fundamental Cerebellar Computation is Intact
title_sort normal motor adaptation in cervical dystonia: a fundamental cerebellar computation is intact
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155166/
https://www.ncbi.nlm.nih.gov/pubmed/24872202
http://dx.doi.org/10.1007/s12311-014-0569-0
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