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CLImAT: accurate detection of copy number alteration and loss of heterozygosity in impure and aneuploid tumor samples using whole-genome sequencing data

Motivation: Whole-genome sequencing of tumor samples has been demonstrated as an efficient approach for comprehensive analysis of genomic aberrations in cancer genome. Critical issues such as tumor impurity and aneuploidy, GC-content and mappability bias have been reported to complicate identificati...

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Detalles Bibliográficos
Autores principales:	Yu, Zhenhua, Liu, Yuanning, Shen, Yi, Wang, Minghui, Li, Ao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155249/ https://www.ncbi.nlm.nih.gov/pubmed/24845652 http://dx.doi.org/10.1093/bioinformatics/btu346

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