Cargando…

A Novel Functional Site in the PB2 Subunit of Influenza A Virus Essential for Acetyl-CoA Interaction, RNA Polymerase Activity, and Viral Replication

The PA, PB1, and PB2 subunits, components of the RNA-dependent RNA polymerase of influenza A virus, are essential for viral transcription and replication. The PB2 subunit binds to the host RNA cap (7-methylguanosine triphosphate (m(7)GTP)) and supports the endonuclease activity of PA to “snatch” the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hatakeyama, Dai, Shoji, Masaki, Yamayoshi, Seiya, Hirota, Takenori, Nagae, Monami, Yanagisawa, Shin, Nakano, Masahiro, Ohmi, Naho, Noda, Takeshi, Kawaoka, Yoshihiro, Kuzuhara, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155666/ https://www.ncbi.nlm.nih.gov/pubmed/25063805 http://dx.doi.org/10.1074/jbc.M114.559708

Ejemplares similares

Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5
por: Hatakeyama, Dai, et al.
Publicado: (2018)

G Protein Pathway Suppressor 1 Promotes Influenza Virus Polymerase Activity by Activating the NF-κB Signaling Pathway
por: Kuwahara, Tomoko, et al.
Publicado: (2019)

The accuracy of reverse genetics systems for SARS‐CoV‐2: Circular polymerase extension reaction versus bacterial artificial chromosome
por: Furusawa, Yuri, et al.
Publicado: (2023)

Strain-Specific Contribution of Eukaryotic Elongation Factor 1 Gamma to the Translation of Influenza A Virus Proteins
por: Sammaibashi, Shuhei, et al.
Publicado: (2018)

Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity
por: Oishi, Kohei, et al.
Publicado: (2019)

Triple combination therapy of favipiravir plus two monoclonal antibodies eradicates influenza virus from nude mice
por: Kiso, Maki, et al.
Publicado: (2020)

Sensitivity of Commercially Available Influenza Rapid Diagnostic Tests in the 2018–2019 Influenza Season
por: Sakai-Tagawa, Yuko, et al.
Publicado: (2019)

Acetyl-CoA Carboxylases and Diseases
por: Wang, Yu, et al.
Publicado: (2022)

ACETYL-COA SYNTHETASE REGULATES HISTONE ACETYLATION AND HIPPOCAMPAL MEMORY
por: Mews, Philipp, et al.
Publicado: (2017)

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
por: Bradshaw, Patrick C.
Publicado: (2021)

Amino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts
por: Yamayoshi, Seiya, et al.
Publicado: (2015)

In-vitro acetylation of SARS-CoV and SARS-CoV-2 nucleocapsid proteins by human PCAF and GCN5
por: Hatakeyama, Dai, et al.
Publicado: (2021)

Chemical Genetics of Acetyl-CoA Carboxylases
por: Zu, Xuyu, et al.
Publicado: (2013)

Genome-Wide Identification and Expression Analysis of the Biotin Carboxyl Carrier Subunits of Heteromeric Acetyl-CoA Carboxylase in Gossypium
por: Cui, Yupeng, et al.
Publicado: (2017)

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses
por: Houston, Ryan, et al.
Publicado: (2020)

NMR spectra of PB2 627, the RNA-binding domain in influenza A virus RNA polymerase that contains the pathogenicity factor lysine 627, and improvement of the spectra by small osmolytes
por: Kato, Yusuke S., et al.
Publicado: (2017)

Treatment of Highly Pathogenic H7N9 Virus-Infected Mice with Baloxavir Marboxil
por: Kiso, Maki, et al.
Publicado: (2019)

Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2
por: Sakai-Tagawa, Yuko, et al.
Publicado: (2021)

Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit
por: Ma, Xiaolei, et al.
Publicado: (2017)

Acetyl-CoA and the Regulation of Metabolism: Mechanisms and Consequences
por: Shi, Lei, et al.
Publicado: (2015)

The dynamic organization of fungal acetyl-CoA carboxylase
por: Hunkeler, Moritz, et al.
Publicado: (2016)

Intracellular Citrate/acetyl-CoA flux and endoplasmic reticulum acetylation: Connectivity is the answer
por: Fernandez-Fuente, Gonzalo, et al.
Publicado: (2022)

The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation
por: Nair, Sethu C., et al.
Publicado: (2023)

Modulation of plant acetyl-CoA synthetase activity by post-translational lysine acetylation
por: Sofeo, Naazneen, et al.
Publicado: (2023)

The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix
por: Long, Joshua C. D., et al.
Publicado: (2016)

Amino acid sites related to the PB2 subunits of IDV affect polymerase activity
por: Wang, Yutian, et al.
Publicado: (2021)

N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in Saccharomyces cerevisiae
por: Varland, Sylvia, et al.
Publicado: (2018)

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
por: Dieterich, Inca A., et al.
Publicado: (2019)

Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression
por: Lozoya, Oswaldo A, et al.
Publicado: (2019)

Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
por: Yamayoshi, Seiya, et al.
Publicado: (2018)

Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses
por: Yasuhara, Atsuhiro, et al.
Publicado: (2018)

Subclade 2.2.1-Specific Human Monoclonal Antibodies That Recognize an Epitope in Antigenic Site A of Influenza A(H5) Virus HA Detected between 2015 and 2018
por: Okuda, Moe, et al.
Publicado: (2019)

In vitro and in vivo characterization of SARS-CoV-2 strains resistant to nirmatrelvir
por: Kiso, Maki, et al.
Publicado: (2023)

Role of Motif III in Catalysis by Acetyl-CoA Synthetase
por: Ingram-Smith, Cheryl, et al.
Publicado: (2012)

Acetyl-CoA-directed gene transcription in cancer cells
por: Martínez-Reyes, Inmaculada, et al.
Publicado: (2018)

Older Than Genes: The Acetyl CoA Pathway and Origins
por: Martin, William F.
Publicado: (2020)

Dynamics of the Degradation of Acetyl-CoA Carboxylase Herbicides in Vegetables
por: Jursík, Miroslav, et al.
Publicado: (2021)

Targeting acetyl-CoA carboxylase 1 for cancer therapy
por: Yu, Yong, et al.
Publicado: (2023)

Gaining access to acetyl-CoA by peroxisomal surface display
por: Perrot, Thomas, et al.
Publicado: (2023)

Nuclear-Cytoplasmic Conflict in Pea (Pisum sativum L.) Is Associated with Nuclear and Plastidic Candidate Genes Encoding Acetyl-CoA Carboxylase Subunits
por: Bogdanova, Vera S., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_d5ib3b71e5vdvore8k9j8r5not