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Role of C Reactive Protein (CRP) in Leptin Resistance

Increased plasma levels of both leptin and C reactive protein (CRP) have been reported in a number of conditions, including obesity, and have been linked to cardiovascular pathophysiological processes and increased cardiovascular risk; interestingly these two biomarkers appear to be able to reciproc...

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Autores principales: Hribal, Marta Letizia, Fiorentino, Teresa Vanessa, Sesti, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155811/
https://www.ncbi.nlm.nih.gov/pubmed/23688010
http://dx.doi.org/10.2174/13816128113199990016
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author Hribal, Marta Letizia
Fiorentino, Teresa Vanessa
Sesti, Giorgio
author_facet Hribal, Marta Letizia
Fiorentino, Teresa Vanessa
Sesti, Giorgio
author_sort Hribal, Marta Letizia
collection PubMed
description Increased plasma levels of both leptin and C reactive protein (CRP) have been reported in a number of conditions, including obesity, and have been linked to cardiovascular pathophysiological processes and increased cardiovascular risk; interestingly these two biomarkers appear to be able to reciprocally regulate their bioavailability, through complex mechanisms that have not been completely clarified yet. Here we first review clinical evidence suggesting not only that the circulatory levels of CRP and leptin show an independent correlation, but also that assessing them in tandem may result in an increased ability to predict cardiovascular disease. We summarize also molecular studies showing that leptin is able to promote CRP production from hepatocytes and endothelial cells in vitro and discuss the studies addressing the possibility that in vivo leptin administration may be able to modulate plasma CRP levels. Furthermore, we describe two studies demonstrating that CRP directly binds leptin in extra-cellular settings, thus impairing its biological actions. Finally we report genetic evidence that common variations at the leptin receptor locus are associated with CRP blood levels. Overall, the data reviewed here show that the chronic elevation of CRP observed in obese subjects may worsen leptin resistance, contributing to the pathogenesis of cardiovascular disease, and highlight a potential link between conditions, such as leptin resistance and endothelial dysfunction, that may be amenable of pharmacological treatment targeted to the disruption of leptin-CRP interaction.
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spelling pubmed-41558112014-09-17 Role of C Reactive Protein (CRP) in Leptin Resistance Hribal, Marta Letizia Fiorentino, Teresa Vanessa Sesti, Giorgio Curr Pharm Des Article Increased plasma levels of both leptin and C reactive protein (CRP) have been reported in a number of conditions, including obesity, and have been linked to cardiovascular pathophysiological processes and increased cardiovascular risk; interestingly these two biomarkers appear to be able to reciprocally regulate their bioavailability, through complex mechanisms that have not been completely clarified yet. Here we first review clinical evidence suggesting not only that the circulatory levels of CRP and leptin show an independent correlation, but also that assessing them in tandem may result in an increased ability to predict cardiovascular disease. We summarize also molecular studies showing that leptin is able to promote CRP production from hepatocytes and endothelial cells in vitro and discuss the studies addressing the possibility that in vivo leptin administration may be able to modulate plasma CRP levels. Furthermore, we describe two studies demonstrating that CRP directly binds leptin in extra-cellular settings, thus impairing its biological actions. Finally we report genetic evidence that common variations at the leptin receptor locus are associated with CRP blood levels. Overall, the data reviewed here show that the chronic elevation of CRP observed in obese subjects may worsen leptin resistance, contributing to the pathogenesis of cardiovascular disease, and highlight a potential link between conditions, such as leptin resistance and endothelial dysfunction, that may be amenable of pharmacological treatment targeted to the disruption of leptin-CRP interaction. Bentham Science Publishers 2014-02 2014-02 /pmc/articles/PMC4155811/ /pubmed/23688010 http://dx.doi.org/10.2174/13816128113199990016 Text en © 2014 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Hribal, Marta Letizia
Fiorentino, Teresa Vanessa
Sesti, Giorgio
Role of C Reactive Protein (CRP) in Leptin Resistance
title Role of C Reactive Protein (CRP) in Leptin Resistance
title_full Role of C Reactive Protein (CRP) in Leptin Resistance
title_fullStr Role of C Reactive Protein (CRP) in Leptin Resistance
title_full_unstemmed Role of C Reactive Protein (CRP) in Leptin Resistance
title_short Role of C Reactive Protein (CRP) in Leptin Resistance
title_sort role of c reactive protein (crp) in leptin resistance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155811/
https://www.ncbi.nlm.nih.gov/pubmed/23688010
http://dx.doi.org/10.2174/13816128113199990016
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