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Secrets of platelet exocytosis – what do we really know about platelet secretion mechanisms?

Upon activation by extracellular matrix components or soluble agonists, platelets release in excess of 300 active molecules from intracellular granules. Those factors can both activate further platelets and mediate a range of responses in other cells. The complex microenvironment of a growing thromb...

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Detalles Bibliográficos
Autores principales: Golebiewska, Ewelina M, Poole, Alastair W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155865/
https://www.ncbi.nlm.nih.gov/pubmed/24588354
http://dx.doi.org/10.1111/bjh.12682
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author Golebiewska, Ewelina M
Poole, Alastair W
author_facet Golebiewska, Ewelina M
Poole, Alastair W
author_sort Golebiewska, Ewelina M
collection PubMed
description Upon activation by extracellular matrix components or soluble agonists, platelets release in excess of 300 active molecules from intracellular granules. Those factors can both activate further platelets and mediate a range of responses in other cells. The complex microenvironment of a growing thrombus, as well as platelets' roles in both physiological and pathological processes, require platelet secretion to be highly spatially and temporally regulated to ensure appropriate responses to a range of stimuli. However, how this regulation is achieved remains incompletely understood. In this review we outline the importance of regulated secretion in thrombosis as well as in ‘novel’ scenarios beyond haemostasis and give a detailed summary of what is known about the molecular mechanisms of platelet exocytosis. We also discuss a number of theories of how different cargoes could be released in a tightly orchestrated manner, allowing complex interactions between platelets and their environment.
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spelling pubmed-41558652014-09-09 Secrets of platelet exocytosis – what do we really know about platelet secretion mechanisms? Golebiewska, Ewelina M Poole, Alastair W Br J Haematol Reviews Upon activation by extracellular matrix components or soluble agonists, platelets release in excess of 300 active molecules from intracellular granules. Those factors can both activate further platelets and mediate a range of responses in other cells. The complex microenvironment of a growing thrombus, as well as platelets' roles in both physiological and pathological processes, require platelet secretion to be highly spatially and temporally regulated to ensure appropriate responses to a range of stimuli. However, how this regulation is achieved remains incompletely understood. In this review we outline the importance of regulated secretion in thrombosis as well as in ‘novel’ scenarios beyond haemostasis and give a detailed summary of what is known about the molecular mechanisms of platelet exocytosis. We also discuss a number of theories of how different cargoes could be released in a tightly orchestrated manner, allowing complex interactions between platelets and their environment. Blackwell Publishing Ltd 2014-04 2013-11-30 /pmc/articles/PMC4155865/ /pubmed/24588354 http://dx.doi.org/10.1111/bjh.12682 Text en Copyright © 2014 John Wiley & Sons Ltd http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Reviews
Golebiewska, Ewelina M
Poole, Alastair W
Secrets of platelet exocytosis – what do we really know about platelet secretion mechanisms?
title Secrets of platelet exocytosis – what do we really know about platelet secretion mechanisms?
title_full Secrets of platelet exocytosis – what do we really know about platelet secretion mechanisms?
title_fullStr Secrets of platelet exocytosis – what do we really know about platelet secretion mechanisms?
title_full_unstemmed Secrets of platelet exocytosis – what do we really know about platelet secretion mechanisms?
title_short Secrets of platelet exocytosis – what do we really know about platelet secretion mechanisms?
title_sort secrets of platelet exocytosis – what do we really know about platelet secretion mechanisms?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155865/
https://www.ncbi.nlm.nih.gov/pubmed/24588354
http://dx.doi.org/10.1111/bjh.12682
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