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Perioperative and postoperative risk factors for corneal graft failure
PURPOSE: In this study, we assessed the outcome of penetrating keratoplasties using organ-cultured corneal tissues at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany. The goal was to identify perioperative and postoperative risk factors that may affect graft survival. PAT...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155896/ https://www.ncbi.nlm.nih.gov/pubmed/25210433 http://dx.doi.org/10.2147/OPTH.S65412 |
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author | Yu, Alice L Kaiser, Michaela Schaumberger, Markus Messmer, Elisabeth Kook, Daniel Welge-Lussen, Ulrich |
author_facet | Yu, Alice L Kaiser, Michaela Schaumberger, Markus Messmer, Elisabeth Kook, Daniel Welge-Lussen, Ulrich |
author_sort | Yu, Alice L |
collection | PubMed |
description | PURPOSE: In this study, we assessed the outcome of penetrating keratoplasties using organ-cultured corneal tissues at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany. The goal was to identify perioperative and postoperative risk factors that may affect graft survival. PATIENTS AND METHODS: The medical records of 377 patients who underwent a penetrating keratoplasty between 2001 and 2011 were reviewed. Organ-cultured corneal tissue was obtained from the eye bank of Ludwig-Maximilians-University. Perioperative and postoperative risk factors for graft failure were evaluated by univariate and multivariate analyses. RESULTS: The 5-year overall survival rate of penetrating keratoplasties was 68%. Graft failure occurred in 26% of patients. High-risk keratoplasties, such as repeat penetrating keratoplasties and emergency penetrating keratoplasties, as well as postoperative conditions, such as glaucoma, retinal surgery, suture problems, persistent epithelial defect, infectious keratitis, and graft rejection, were significantly associated with graft failure in the multivariate analyses. CONCLUSION: This study showed a similar graft-survival rate as demonstrated in previous studies. In addition, a number of perioperative and postoperative risk factors were identified in this specific patient population. |
format | Online Article Text |
id | pubmed-4155896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41558962014-09-10 Perioperative and postoperative risk factors for corneal graft failure Yu, Alice L Kaiser, Michaela Schaumberger, Markus Messmer, Elisabeth Kook, Daniel Welge-Lussen, Ulrich Clin Ophthalmol Original Research PURPOSE: In this study, we assessed the outcome of penetrating keratoplasties using organ-cultured corneal tissues at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany. The goal was to identify perioperative and postoperative risk factors that may affect graft survival. PATIENTS AND METHODS: The medical records of 377 patients who underwent a penetrating keratoplasty between 2001 and 2011 were reviewed. Organ-cultured corneal tissue was obtained from the eye bank of Ludwig-Maximilians-University. Perioperative and postoperative risk factors for graft failure were evaluated by univariate and multivariate analyses. RESULTS: The 5-year overall survival rate of penetrating keratoplasties was 68%. Graft failure occurred in 26% of patients. High-risk keratoplasties, such as repeat penetrating keratoplasties and emergency penetrating keratoplasties, as well as postoperative conditions, such as glaucoma, retinal surgery, suture problems, persistent epithelial defect, infectious keratitis, and graft rejection, were significantly associated with graft failure in the multivariate analyses. CONCLUSION: This study showed a similar graft-survival rate as demonstrated in previous studies. In addition, a number of perioperative and postoperative risk factors were identified in this specific patient population. Dove Medical Press 2014-08-28 /pmc/articles/PMC4155896/ /pubmed/25210433 http://dx.doi.org/10.2147/OPTH.S65412 Text en © 2014 Yu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Yu, Alice L Kaiser, Michaela Schaumberger, Markus Messmer, Elisabeth Kook, Daniel Welge-Lussen, Ulrich Perioperative and postoperative risk factors for corneal graft failure |
title | Perioperative and postoperative risk factors for corneal graft failure |
title_full | Perioperative and postoperative risk factors for corneal graft failure |
title_fullStr | Perioperative and postoperative risk factors for corneal graft failure |
title_full_unstemmed | Perioperative and postoperative risk factors for corneal graft failure |
title_short | Perioperative and postoperative risk factors for corneal graft failure |
title_sort | perioperative and postoperative risk factors for corneal graft failure |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155896/ https://www.ncbi.nlm.nih.gov/pubmed/25210433 http://dx.doi.org/10.2147/OPTH.S65412 |
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