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Perioperative and postoperative risk factors for corneal graft failure

PURPOSE: In this study, we assessed the outcome of penetrating keratoplasties using organ-cultured corneal tissues at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany. The goal was to identify perioperative and postoperative risk factors that may affect graft survival. PAT...

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Autores principales: Yu, Alice L, Kaiser, Michaela, Schaumberger, Markus, Messmer, Elisabeth, Kook, Daniel, Welge-Lussen, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155896/
https://www.ncbi.nlm.nih.gov/pubmed/25210433
http://dx.doi.org/10.2147/OPTH.S65412
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author Yu, Alice L
Kaiser, Michaela
Schaumberger, Markus
Messmer, Elisabeth
Kook, Daniel
Welge-Lussen, Ulrich
author_facet Yu, Alice L
Kaiser, Michaela
Schaumberger, Markus
Messmer, Elisabeth
Kook, Daniel
Welge-Lussen, Ulrich
author_sort Yu, Alice L
collection PubMed
description PURPOSE: In this study, we assessed the outcome of penetrating keratoplasties using organ-cultured corneal tissues at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany. The goal was to identify perioperative and postoperative risk factors that may affect graft survival. PATIENTS AND METHODS: The medical records of 377 patients who underwent a penetrating keratoplasty between 2001 and 2011 were reviewed. Organ-cultured corneal tissue was obtained from the eye bank of Ludwig-Maximilians-University. Perioperative and postoperative risk factors for graft failure were evaluated by univariate and multivariate analyses. RESULTS: The 5-year overall survival rate of penetrating keratoplasties was 68%. Graft failure occurred in 26% of patients. High-risk keratoplasties, such as repeat penetrating keratoplasties and emergency penetrating keratoplasties, as well as postoperative conditions, such as glaucoma, retinal surgery, suture problems, persistent epithelial defect, infectious keratitis, and graft rejection, were significantly associated with graft failure in the multivariate analyses. CONCLUSION: This study showed a similar graft-survival rate as demonstrated in previous studies. In addition, a number of perioperative and postoperative risk factors were identified in this specific patient population.
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spelling pubmed-41558962014-09-10 Perioperative and postoperative risk factors for corneal graft failure Yu, Alice L Kaiser, Michaela Schaumberger, Markus Messmer, Elisabeth Kook, Daniel Welge-Lussen, Ulrich Clin Ophthalmol Original Research PURPOSE: In this study, we assessed the outcome of penetrating keratoplasties using organ-cultured corneal tissues at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany. The goal was to identify perioperative and postoperative risk factors that may affect graft survival. PATIENTS AND METHODS: The medical records of 377 patients who underwent a penetrating keratoplasty between 2001 and 2011 were reviewed. Organ-cultured corneal tissue was obtained from the eye bank of Ludwig-Maximilians-University. Perioperative and postoperative risk factors for graft failure were evaluated by univariate and multivariate analyses. RESULTS: The 5-year overall survival rate of penetrating keratoplasties was 68%. Graft failure occurred in 26% of patients. High-risk keratoplasties, such as repeat penetrating keratoplasties and emergency penetrating keratoplasties, as well as postoperative conditions, such as glaucoma, retinal surgery, suture problems, persistent epithelial defect, infectious keratitis, and graft rejection, were significantly associated with graft failure in the multivariate analyses. CONCLUSION: This study showed a similar graft-survival rate as demonstrated in previous studies. In addition, a number of perioperative and postoperative risk factors were identified in this specific patient population. Dove Medical Press 2014-08-28 /pmc/articles/PMC4155896/ /pubmed/25210433 http://dx.doi.org/10.2147/OPTH.S65412 Text en © 2014 Yu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Yu, Alice L
Kaiser, Michaela
Schaumberger, Markus
Messmer, Elisabeth
Kook, Daniel
Welge-Lussen, Ulrich
Perioperative and postoperative risk factors for corneal graft failure
title Perioperative and postoperative risk factors for corneal graft failure
title_full Perioperative and postoperative risk factors for corneal graft failure
title_fullStr Perioperative and postoperative risk factors for corneal graft failure
title_full_unstemmed Perioperative and postoperative risk factors for corneal graft failure
title_short Perioperative and postoperative risk factors for corneal graft failure
title_sort perioperative and postoperative risk factors for corneal graft failure
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155896/
https://www.ncbi.nlm.nih.gov/pubmed/25210433
http://dx.doi.org/10.2147/OPTH.S65412
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