Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody

Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly regulated in healthy individuals by the serpin C1-inhibitor, but individuals with hereditary angioedema (HAE) are...

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Detalles Bibliográficos
Autores principales: Kenniston, Jon A., Faucette, Ryan R., Martik, Diana, Comeau, Stephen R., Lindberg, Allison P., Kopacz, Kris J., Conley, Gregory P., Chen, Jie, Viswanathan, Malini, Kastrapeli, Niksa, Cosic, Janja, Mason, Shauna, DiLeo, Mike, Abendroth, Jan, Kuzmic, Petr, Ladner, Robert C., Edwards, Thomas E., TenHoor, Christopher, Adelman, Burt A., Nixon, Andrew E., Sexton, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156074/
https://www.ncbi.nlm.nih.gov/pubmed/24970892
http://dx.doi.org/10.1074/jbc.M114.569061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156074/
https://www.ncbi.nlm.nih.gov/pubmed/24970892
http://dx.doi.org/10.1074/jbc.M114.569061

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