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Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody
Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly regulated in healthy individuals by the serpin C1-inhibitor, but individuals with hereditary angioedema (HAE) are...
Autores principales: | Kenniston, Jon A., Faucette, Ryan R., Martik, Diana, Comeau, Stephen R., Lindberg, Allison P., Kopacz, Kris J., Conley, Gregory P., Chen, Jie, Viswanathan, Malini, Kastrapeli, Niksa, Cosic, Janja, Mason, Shauna, DiLeo, Mike, Abendroth, Jan, Kuzmic, Petr, Ladner, Robert C., Edwards, Thomas E., TenHoor, Christopher, Adelman, Burt A., Nixon, Andrew E., Sexton, Daniel J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156074/ https://www.ncbi.nlm.nih.gov/pubmed/24970892 http://dx.doi.org/10.1074/jbc.M114.569061 |
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