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Structural Insights into the Activation of the RhoA GTPase by the Lymphoid Blast Crisis (Lbc) Oncoprotein

The small GTPase RhoA promotes deregulated signaling upon interaction with lymphoid blast crisis (Lbc), the oncogenic form of A-kinase anchoring protein 13 (AKAP13). The onco-Lbc protein is a hyperactive Rho-specific guanine nucleotide exchange factor (GEF), but its structural mechanism has not been...

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Detalles Bibliográficos
Autores principales:	Lenoir, Marc, Sugawara, Masae, Kaur, Jaswant, Ball, Linda J., Overduin, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156082/ https://www.ncbi.nlm.nih.gov/pubmed/24993829 http://dx.doi.org/10.1074/jbc.M114.561787

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