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Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1ϵ and Frizzled5

Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation by Wnt ligands. Casein kinase 1ϵ (CK1ϵ) was identified as the major kinase responsible for Wnt-induced Dvl3 phosphorylati...

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Detalles Bibliográficos
Autores principales:	Bernatík, Ondřej, Šedová, Kateřina, Schille, Carolin, Ganji, Ranjani Sri, Červenka, Igor, Trantírek, Lukáš, Schambony, Alexandra, Zdráhal, Zbyněk, Bryja, Vítězslav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156093/ https://www.ncbi.nlm.nih.gov/pubmed/24993822 http://dx.doi.org/10.1074/jbc.M114.590638

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