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Cystitis glandularis: A controversial premalignant lesion

Cystitis glandularis (CG) has been hypothesized as a potential precursor of adenocarcinoma, although this remains controversial. The present study reports data accumulated from 166 cases of cystitis glandularis with follow-up periods ranging between 0.5 and 17 years. The association between intestin...

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Autores principales: YI, XIANLIN, LU, HAOYUAN, WU, YUEXIAN, SHEN, YANG, MENG, QINGGUI, CHENG, JIWENG, TANG, YONG, WU, FENGXUE, OU, RUBIAO, JIANG, SHAOJUN, BAI, XIANZHONG, XIE, KEJI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156188/
https://www.ncbi.nlm.nih.gov/pubmed/25202387
http://dx.doi.org/10.3892/ol.2014.2360
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author YI, XIANLIN
LU, HAOYUAN
WU, YUEXIAN
SHEN, YANG
MENG, QINGGUI
CHENG, JIWENG
TANG, YONG
WU, FENGXUE
OU, RUBIAO
JIANG, SHAOJUN
BAI, XIANZHONG
XIE, KEJI
author_facet YI, XIANLIN
LU, HAOYUAN
WU, YUEXIAN
SHEN, YANG
MENG, QINGGUI
CHENG, JIWENG
TANG, YONG
WU, FENGXUE
OU, RUBIAO
JIANG, SHAOJUN
BAI, XIANZHONG
XIE, KEJI
author_sort YI, XIANLIN
collection PubMed
description Cystitis glandularis (CG) has been hypothesized as a potential precursor of adenocarcinoma, although this remains controversial. The present study reports data accumulated from 166 cases of cystitis glandularis with follow-up periods ranging between 0.5 and 17 years. The association between intestinal and typical CG and bladder carcinoma was retrospectively evaluated. The patients included in the present study had presented with typical (n=155) or intestinal (n=11) CG between 1994 and 2010. Of those patients, concurrent carcinoma of the bladder was identified in 15 (9.0%) patients, including two cases of squamous cell carcinoma and 1 case of sarcoma. The cases of carcinoma were identified either prior to or concurrently with the diagnosis of CG. Follow-up was available for 9/11 (81.8%) patients with intestinal CG. Nine months following transurethral fulguration, 8/11 (72.7%) patients were in complete remission and 1/11 (9.1%) complained of urgency and dysuria; two patients were lost to follow-up. The follow-up of the patients ranged from 0.7 to 4.5 years (median, 2.67 years; mean, 2.82 years). No evidence of subsequent carcinoma was identified in any of the patients during the follow-up of the intestinal and typical CG groups. In addition, there was no evidence of carcinoma subsequent to CG in either of the typical or intestinal CG groups. The results did not support that CG increases the future risk of malignancy in the short term and repeated cystoscopies over a short period of time are not recommended.
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spelling pubmed-41561882014-09-08 Cystitis glandularis: A controversial premalignant lesion YI, XIANLIN LU, HAOYUAN WU, YUEXIAN SHEN, YANG MENG, QINGGUI CHENG, JIWENG TANG, YONG WU, FENGXUE OU, RUBIAO JIANG, SHAOJUN BAI, XIANZHONG XIE, KEJI Oncol Lett Articles Cystitis glandularis (CG) has been hypothesized as a potential precursor of adenocarcinoma, although this remains controversial. The present study reports data accumulated from 166 cases of cystitis glandularis with follow-up periods ranging between 0.5 and 17 years. The association between intestinal and typical CG and bladder carcinoma was retrospectively evaluated. The patients included in the present study had presented with typical (n=155) or intestinal (n=11) CG between 1994 and 2010. Of those patients, concurrent carcinoma of the bladder was identified in 15 (9.0%) patients, including two cases of squamous cell carcinoma and 1 case of sarcoma. The cases of carcinoma were identified either prior to or concurrently with the diagnosis of CG. Follow-up was available for 9/11 (81.8%) patients with intestinal CG. Nine months following transurethral fulguration, 8/11 (72.7%) patients were in complete remission and 1/11 (9.1%) complained of urgency and dysuria; two patients were lost to follow-up. The follow-up of the patients ranged from 0.7 to 4.5 years (median, 2.67 years; mean, 2.82 years). No evidence of subsequent carcinoma was identified in any of the patients during the follow-up of the intestinal and typical CG groups. In addition, there was no evidence of carcinoma subsequent to CG in either of the typical or intestinal CG groups. The results did not support that CG increases the future risk of malignancy in the short term and repeated cystoscopies over a short period of time are not recommended. D.A. Spandidos 2014-10 2014-07-18 /pmc/articles/PMC4156188/ /pubmed/25202387 http://dx.doi.org/10.3892/ol.2014.2360 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
YI, XIANLIN
LU, HAOYUAN
WU, YUEXIAN
SHEN, YANG
MENG, QINGGUI
CHENG, JIWENG
TANG, YONG
WU, FENGXUE
OU, RUBIAO
JIANG, SHAOJUN
BAI, XIANZHONG
XIE, KEJI
Cystitis glandularis: A controversial premalignant lesion
title Cystitis glandularis: A controversial premalignant lesion
title_full Cystitis glandularis: A controversial premalignant lesion
title_fullStr Cystitis glandularis: A controversial premalignant lesion
title_full_unstemmed Cystitis glandularis: A controversial premalignant lesion
title_short Cystitis glandularis: A controversial premalignant lesion
title_sort cystitis glandularis: a controversial premalignant lesion
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156188/
https://www.ncbi.nlm.nih.gov/pubmed/25202387
http://dx.doi.org/10.3892/ol.2014.2360
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