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Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)

Histological tumor necrosis (TN) has been reported to indicate a poor prognosis for different human cancers. It is generally accepted that TN results from chronic ischemic injury due to rapid tumor growth. However, whether insufficient tumor vascularization and inadequate tumor cell oxygenation are...

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Autores principales: CARUSO, ROSARIO A., BRANCA, GIOVANNI, FEDELE, FRANCESCO, IRATO, ELEONORA, FINOCCHIARO, GIUSEPPE, PARISI, ANTONIO, IENI, ANTONIO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156238/
https://www.ncbi.nlm.nih.gov/pubmed/25202341
http://dx.doi.org/10.3892/ol.2014.2345
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author CARUSO, ROSARIO A.
BRANCA, GIOVANNI
FEDELE, FRANCESCO
IRATO, ELEONORA
FINOCCHIARO, GIUSEPPE
PARISI, ANTONIO
IENI, ANTONIO
author_facet CARUSO, ROSARIO A.
BRANCA, GIOVANNI
FEDELE, FRANCESCO
IRATO, ELEONORA
FINOCCHIARO, GIUSEPPE
PARISI, ANTONIO
IENI, ANTONIO
author_sort CARUSO, ROSARIO A.
collection PubMed
description Histological tumor necrosis (TN) has been reported to indicate a poor prognosis for different human cancers. It is generally accepted that TN results from chronic ischemic injury due to rapid tumor growth. However, whether insufficient tumor vascularization and inadequate tumor cell oxygenation are the only factors causing TN remains controversial. Mitotic catastrophe is considered to occur as a result of dysregulated/failed mitosis, leading to cell death. We hypothesize that mitotic catastrophe, induced by hypoxic stress, may lead to the TN which is observed in high grade carcinomas. The current review describes the morphological features of TN in malignant epithelial tumors. In addition, evidence regarding the involvement of mitotic catastrophe in the induction of TN in human carcinomas is discussed.
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spelling pubmed-41562382014-09-08 Mechanisms of coagulative necrosis in malignant epithelial tumors (Review) CARUSO, ROSARIO A. BRANCA, GIOVANNI FEDELE, FRANCESCO IRATO, ELEONORA FINOCCHIARO, GIUSEPPE PARISI, ANTONIO IENI, ANTONIO Oncol Lett Articles Histological tumor necrosis (TN) has been reported to indicate a poor prognosis for different human cancers. It is generally accepted that TN results from chronic ischemic injury due to rapid tumor growth. However, whether insufficient tumor vascularization and inadequate tumor cell oxygenation are the only factors causing TN remains controversial. Mitotic catastrophe is considered to occur as a result of dysregulated/failed mitosis, leading to cell death. We hypothesize that mitotic catastrophe, induced by hypoxic stress, may lead to the TN which is observed in high grade carcinomas. The current review describes the morphological features of TN in malignant epithelial tumors. In addition, evidence regarding the involvement of mitotic catastrophe in the induction of TN in human carcinomas is discussed. D.A. Spandidos 2014-10 2014-07-11 /pmc/articles/PMC4156238/ /pubmed/25202341 http://dx.doi.org/10.3892/ol.2014.2345 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
CARUSO, ROSARIO A.
BRANCA, GIOVANNI
FEDELE, FRANCESCO
IRATO, ELEONORA
FINOCCHIARO, GIUSEPPE
PARISI, ANTONIO
IENI, ANTONIO
Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)
title Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)
title_full Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)
title_fullStr Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)
title_full_unstemmed Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)
title_short Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)
title_sort mechanisms of coagulative necrosis in malignant epithelial tumors (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156238/
https://www.ncbi.nlm.nih.gov/pubmed/25202341
http://dx.doi.org/10.3892/ol.2014.2345
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