The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro

Peptides from scorpion venom have been previously studied for use in the prevention and treatment of various types of cancer in folk medicine. The present study investigated the anti-proliferative effects and mechanisms of the low molecular weight (~3 kDa) BmK scorpion venom peptides (LMWSVP) on hum...

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Autores principales: LI, WEILING, XIN, YI, CHEN, YANG, LI, XINLI, ZHANG, CUILI, BAI, JING, YUAN, JIELI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156272/
https://www.ncbi.nlm.nih.gov/pubmed/25202371
http://dx.doi.org/10.3892/ol.2014.2336
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author LI, WEILING
XIN, YI
CHEN, YANG
LI, XINLI
ZHANG, CUILI
BAI, JING
YUAN, JIELI
author_facet LI, WEILING
XIN, YI
CHEN, YANG
LI, XINLI
ZHANG, CUILI
BAI, JING
YUAN, JIELI
author_sort LI, WEILING
collection PubMed
description Peptides from scorpion venom have been previously studied for use in the prevention and treatment of various types of cancer in folk medicine. The present study investigated the anti-proliferative effects and mechanisms of the low molecular weight (~3 kDa) BmK scorpion venom peptides (LMWSVP) on human hepatoma (SMMC 7721) and cervical carcinoma (HeLa) cells. The data indicated that LMWSVP inhibited the growth of SMMC 7721 cells, but had no effect on the growth of HeLa cells. SMMC 7721 cells were more sensitive, with a higher affinity, to LMWSVP as compared with HeLa cells. In addition, LMWSVP induced apoptosis of SMMC 7721 cells by upregulating the expression of caspase-3 and downregulating the expression of Bcl-2. These data provide an experimental basis for further purification and application of LMWSVP for use as an anti-tumor drug in clinical trials.
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spelling pubmed-41562722014-09-08 The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro LI, WEILING XIN, YI CHEN, YANG LI, XINLI ZHANG, CUILI BAI, JING YUAN, JIELI Oncol Lett Articles Peptides from scorpion venom have been previously studied for use in the prevention and treatment of various types of cancer in folk medicine. The present study investigated the anti-proliferative effects and mechanisms of the low molecular weight (~3 kDa) BmK scorpion venom peptides (LMWSVP) on human hepatoma (SMMC 7721) and cervical carcinoma (HeLa) cells. The data indicated that LMWSVP inhibited the growth of SMMC 7721 cells, but had no effect on the growth of HeLa cells. SMMC 7721 cells were more sensitive, with a higher affinity, to LMWSVP as compared with HeLa cells. In addition, LMWSVP induced apoptosis of SMMC 7721 cells by upregulating the expression of caspase-3 and downregulating the expression of Bcl-2. These data provide an experimental basis for further purification and application of LMWSVP for use as an anti-tumor drug in clinical trials. D.A. Spandidos 2014-10 2014-07-10 /pmc/articles/PMC4156272/ /pubmed/25202371 http://dx.doi.org/10.3892/ol.2014.2336 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
LI, WEILING
XIN, YI
CHEN, YANG
LI, XINLI
ZHANG, CUILI
BAI, JING
YUAN, JIELI
The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro
title The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro
title_full The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro
title_fullStr The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro
title_full_unstemmed The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro
title_short The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro
title_sort anti-proliferative effects and mechanisms of low molecular weight scorpion bmk venom peptides on human hepatoma and cervical carcinoma cells in vitro
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156272/
https://www.ncbi.nlm.nih.gov/pubmed/25202371
http://dx.doi.org/10.3892/ol.2014.2336
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