The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity

Staufen (Stau) proteins belong to a family of RNA-binding proteins (RBPs) that are important for RNA localisation in many organisms. In this review we discuss recent findings on the conserved role played by Stau during both the early differentiation of neurons and in the synaptic plasticity of matur...

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Detalles Bibliográficos
Autores principales: Heraud-Farlow, Jacki E., Kiebler, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Applied Science Publishing 2014
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156307/
https://www.ncbi.nlm.nih.gov/pubmed/25012293
http://dx.doi.org/10.1016/j.tins.2014.05.009
Descripción
Sumario:Staufen (Stau) proteins belong to a family of RNA-binding proteins (RBPs) that are important for RNA localisation in many organisms. In this review we discuss recent findings on the conserved role played by Stau during both the early differentiation of neurons and in the synaptic plasticity of mature neurons. Recent molecular data suggest mechanisms for how Stau2 regulates mRNA localisation, mRNA stability, translation, and ribonucleoprotein (RNP) assembly. We offer a perspective on how this multifunctional RBP has been adopted to regulate mRNA localisation under several different cellular and developmental conditions.

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