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Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis

OBJECTIVE: Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has recently been reported to be a marker of cancer stem cells (CSCs) in colorectal cancer (CRC), and the prognostic value of LGR5 in CRC has been evaluated in several studies. However, the conclusions remain controversial...

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Autores principales: Chen, Qing, Zhang, Xin, Li, Wei-Min, Ji, Yu-Qiang, Cao, Hao-Zhe, Zheng, Pengsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156381/
https://www.ncbi.nlm.nih.gov/pubmed/25192390
http://dx.doi.org/10.1371/journal.pone.0107013
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author Chen, Qing
Zhang, Xin
Li, Wei-Min
Ji, Yu-Qiang
Cao, Hao-Zhe
Zheng, Pengsheng
author_facet Chen, Qing
Zhang, Xin
Li, Wei-Min
Ji, Yu-Qiang
Cao, Hao-Zhe
Zheng, Pengsheng
author_sort Chen, Qing
collection PubMed
description OBJECTIVE: Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has recently been reported to be a marker of cancer stem cells (CSCs) in colorectal cancer (CRC), and the prognostic value of LGR5 in CRC has been evaluated in several studies. However, the conclusions remain controversial. In this study, we aimed to evaluate the association between the expression of LGR5 and the outcome of CRC patients by performing a meta-analysis. METHODS: We systematically searched for relevant studies published up to February 2014 using the PubMed, Web of Science, EMBASE and Wangfang databases. Only articles in which LGR5 expression was detected by immunohistochemistry were included. A meta-analysis was performed using STATA 12.0, and pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to estimate the strength of the association between LGR5 expression and the prognosis of CRC patients. RESULTS: A total of 7 studies comprising 1833 CRC patients met the inclusion criteria, including 6 studies comprising 1781 patients for overall survival (OS) and 3 studies comprising 528 patients for disease-free survival (DFS). Our results showed that high LGR5 expression was significantly associated with poor prognosis in terms of OS (HR: 1.87, 95% CI: 1.23–2.84; P = 0.003) and DFS (HR: 2.44, 95% CI: 1.49–3.98; P<0.001). Further subgroup analysis revealed that many factors, including the study region, number of patients, follow-up duration and cutoff value, affected the significance of the association between LGR5 expression and a worse prognosis in patients with CRC. In addition, there was no evidence of publication bias, as suggested by Begg’s and Egger’s tests. CONCLUSIONS: The present meta-analysis indicated that high LGR5 expression was associated with poor prognosis in patients with CRC and that LGR5 is an efficient prognostic factor in CRC.
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spelling pubmed-41563812014-09-09 Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis Chen, Qing Zhang, Xin Li, Wei-Min Ji, Yu-Qiang Cao, Hao-Zhe Zheng, Pengsheng PLoS One Research Article OBJECTIVE: Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has recently been reported to be a marker of cancer stem cells (CSCs) in colorectal cancer (CRC), and the prognostic value of LGR5 in CRC has been evaluated in several studies. However, the conclusions remain controversial. In this study, we aimed to evaluate the association between the expression of LGR5 and the outcome of CRC patients by performing a meta-analysis. METHODS: We systematically searched for relevant studies published up to February 2014 using the PubMed, Web of Science, EMBASE and Wangfang databases. Only articles in which LGR5 expression was detected by immunohistochemistry were included. A meta-analysis was performed using STATA 12.0, and pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to estimate the strength of the association between LGR5 expression and the prognosis of CRC patients. RESULTS: A total of 7 studies comprising 1833 CRC patients met the inclusion criteria, including 6 studies comprising 1781 patients for overall survival (OS) and 3 studies comprising 528 patients for disease-free survival (DFS). Our results showed that high LGR5 expression was significantly associated with poor prognosis in terms of OS (HR: 1.87, 95% CI: 1.23–2.84; P = 0.003) and DFS (HR: 2.44, 95% CI: 1.49–3.98; P<0.001). Further subgroup analysis revealed that many factors, including the study region, number of patients, follow-up duration and cutoff value, affected the significance of the association between LGR5 expression and a worse prognosis in patients with CRC. In addition, there was no evidence of publication bias, as suggested by Begg’s and Egger’s tests. CONCLUSIONS: The present meta-analysis indicated that high LGR5 expression was associated with poor prognosis in patients with CRC and that LGR5 is an efficient prognostic factor in CRC. Public Library of Science 2014-09-05 /pmc/articles/PMC4156381/ /pubmed/25192390 http://dx.doi.org/10.1371/journal.pone.0107013 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chen, Qing
Zhang, Xin
Li, Wei-Min
Ji, Yu-Qiang
Cao, Hao-Zhe
Zheng, Pengsheng
Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis
title Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis
title_full Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis
title_fullStr Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis
title_full_unstemmed Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis
title_short Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis
title_sort prognostic value of lgr5 in colorectal cancer: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156381/
https://www.ncbi.nlm.nih.gov/pubmed/25192390
http://dx.doi.org/10.1371/journal.pone.0107013
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