Cargando…

Crystal Structure of Transglutaminase 2 with GTP Complex and Amino Acid Sequence Evidence of Evolution of GTP Binding Site

Transglutaminase2 (TG2) is a multi-functional protein involved in various cellular processes, including apoptosis, differentiation, wound healing, and angiogenesis. The malfunction of TG2 causes many human disease including inflammatory disease, celiac disease, neurodegenerative diseases, tissue fib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jang, Tae-Ho, Lee, Dong-Sup, Choi, Kihang, Jeong, Eui Man, Kim, In-Gyu, Kim, Young Whan, Chun, Jung Nyeo, Jeon, Ju-Hong, Park, Hyun Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156391/ https://www.ncbi.nlm.nih.gov/pubmed/25192068 http://dx.doi.org/10.1371/journal.pone.0107005

Ejemplares similares

Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2
por: Jeong, Eui Man, et al.
Publicado: (2020)

A Calcium- and GTP-Dependent Transglutaminase in Leishmania infantum
por: Almugadam, Shawgi Hago, et al.
Publicado: (2023)

Comprehensive Characterization of (S)GTP-Binding Proteins by Orthogonal Quantitative (S)GTP-Affinity Profiling and (S)GTP/GTP Competition Assays
por: Xiao, Yongsheng, et al.
Publicado: (2014)

Structural basis of IRGB10 oligomerization by GTP hydrolysis
por: Ha, Hyun Ji, et al.
Publicado: (2023)

An intermolecular G-quadruplex as the basis for GTP recognition in the class V–GTP aptamer
por: Nasiri, Amir H., et al.
Publicado: (2016)

The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability
por: Roostalu, Johanna, et al.
Publicado: (2020)

Allosteric site variants affect GTP hydrolysis on Ras
por: Johnson, Christian W., et al.
Publicado: (2023)

A GTP signal to the nucleolus
por: Tuma, Rbiya S.
Publicado: (2005)

Going in GTP cycles in the nucleolus
por: Misteli, Tom
Publicado: (2005)

Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells
por: Kumar, Anupam, et al.
Publicado: (2012)

Induction of Ran GTP drives ciliogenesis
por: Fan, Shuling, et al.
Publicado: (2011)

Reconstitution of microtubule into GTP-responsive nanocapsules
por: Uchida, Noriyuki, et al.
Publicado: (2022)

Blue News Update: BODIPY-GTP Binds to the Blue-Light Receptor YtvA While GTP Does Not
por: Dorn, Matthias, et al.
Publicado: (2012)

The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity
por: Barnes, Christopher O., et al.
Publicado: (2019)

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
por: Taymans, Jean-Marc, et al.
Publicado: (2011)

Citrate Regulates the Saccharomyces cerevisiae Mitochondrial GDP/GTP Carrier (Ggc1p) by Triggering Unidirectional Transport of GTP
por: Seccia, Roberta, et al.
Publicado: (2022)

Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-Luc(GTP&ATP) assay
por: Kopra, Kari, et al.
Publicado: (2023)

Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival
por: Kerr, Candace, et al.
Publicado: (2016)

Structural insights into the mechanism of GTP initiation of microtubule assembly
por: Zhou, Ju, et al.
Publicado: (2023)

GTP-binding proteins as oncogenes in human tumors.
por: McCormick, F
Publicado: (1991)

Dynamic structure of membrane-anchored Arf•GTP
por: Liu, Yizhou, et al.
Publicado: (2010)

GTP-Binding Proteins and Formation of Secretory Vesicles
por: LEYTE, ANJA, et al.
Publicado: (1993)

Unveiling the catalytic mechanism of GTP hydrolysis in microtubules
por: Beckett, Daniel, et al.
Publicado: (2023)

GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe
por: Piedra, Felipe-Andrés, et al.
Publicado: (2016)

High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP
por: Schumacher, Maria A., et al.
Publicado: (2020)

Molybdopterin Biosynthesis: Trapping of Intermediates for the MoaA-Catalyzed Reaction Using 2′-DeoxyGTP and 2′-ChloroGTP as Substrate Analogues.
por: Mehta, Angad P., et al.
Publicado: (2014)

Incorporating efficient radial basis function networks and significant amino acid pairs for predicting GTP binding sites in transport proteins
por: Le, Nguyen-Quoc-Khanh, et al.
Publicado: (2016)

Structural Basis for GTP-Dependent Dimerization of Hydrogenase Maturation Factor HypB
por: Chan, Kwok-Ho, et al.
Publicado: (2012)

Localization of GTP-stimulated core glycosylation to fused microsomes
Publicado: (1983)

A Novel Class of RanGTP Binding Proteins
por: Görlich, Dirk, et al.
Publicado: (1997)

Responses of the ciliates Tetrahymena and Paramecium to external ATP and GTP
por: Hennessey, Todd M.
Publicado: (2005)

Integration of membrane proteins into the endoplasmic reticulum requires GTP
Publicado: (1988)

The Protein Partners of GTP Cyclohydrolase I in Rat Organs
por: Du, Jianhai, et al.
Publicado: (2012)

Translation initiation without IF2-dependent GTP hydrolysis
por: Fabbretti, Attilio, et al.
Publicado: (2012)

Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolò E., et al.
Publicado: (2014)

Mechanism of Allosteric Activation of SAMHD1 by dGTP
por: Ji, Xiaoyun, et al.
Publicado: (2013)

A multidrug ABC transporter with a taste for GTP
por: Orelle, Cédric, et al.
Publicado: (2018)

Structural impact of GTP binding on downstream KRAS signaling
por: Menyhárd, Dóra K., et al.
Publicado: (2020)

The role of GTP hydrolysis by EF-G in ribosomal translocation
por: Rexroad, Gillian, et al.
Publicado: (2022)

Preparation, Characterization, and In Vivo Evaluation of Gentiopicroside-Phospholipid Complex (GTP-PC) and Its Self-Nanoemulsion Drug Delivery System (GTP-PC-SNEDDS)
por: Tong, Yingpeng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pjm3gdv3rui8qvoju4jp8fuq9i