Potential Therapeutic Benefit of C1-Esterase Inhibitor in Neuromyelitis Optica Evaluated In Vitro and in an Experimental Rat Model

Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system in which binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to astrocytes causes complement-dependent cytotoxicity (CDC) and inflammation resulting in oligodendrocyte and neuronal injury. There i...

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Detalles Bibliográficos
Autores principales: Tradtrantip, Lukmanee, Asavapanumas, Nithi, Phuan, Puay-Wah, Verkman, A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156393/
https://www.ncbi.nlm.nih.gov/pubmed/25191939
http://dx.doi.org/10.1371/journal.pone.0106824

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