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Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study

OBJECTIVE: Previous studies have suggested that C-reactive protein (CRP) was associated with risk of stroke. There were few studies in Asian population, or on stroke subtypes other than ischemic stroke. We thus investigated the relationship between CRP and the risks of all stroke and its subtypes in...

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Autores principales: Liu, Yanfang, Wang, Jing, Zhang, Liqun, Wang, Chunxue, Wu, Jianwei, Zhou, Yong, Gao, Xiang, Wang, Anxin, Wu, Shouling, Zhao, Xingquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156395/
https://www.ncbi.nlm.nih.gov/pubmed/25191699
http://dx.doi.org/10.1371/journal.pone.0107017
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author Liu, Yanfang
Wang, Jing
Zhang, Liqun
Wang, Chunxue
Wu, Jianwei
Zhou, Yong
Gao, Xiang
Wang, Anxin
Wu, Shouling
Zhao, Xingquan
author_facet Liu, Yanfang
Wang, Jing
Zhang, Liqun
Wang, Chunxue
Wu, Jianwei
Zhou, Yong
Gao, Xiang
Wang, Anxin
Wu, Shouling
Zhao, Xingquan
author_sort Liu, Yanfang
collection PubMed
description OBJECTIVE: Previous studies have suggested that C-reactive protein (CRP) was associated with risk of stroke. There were few studies in Asian population, or on stroke subtypes other than ischemic stroke. We thus investigated the relationship between CRP and the risks of all stroke and its subtypes in a Chinese adult population. METHODS: In the current study, we included 90,517 Chinese adults free of stroke and myocardial infarction at baseline (June 2006 to October 2007) in analyses. Strokes were classified as ischemic stroke (IS), intracranial heamorrhage (ICH) and subarachnoid heamorrhage (SAH). High-sensitivity CRP (hs-CRP) were categorized into three groups: <1 mg/L, 1 to 3 mg/L, and >3 mg/L. Cox proportional hazards regression was used to calculate the association between hs-CRP concentrations and all stroke, as well as its subtypes. RESULTS: During a median follow-up time of 49 months, we documented 1,472 incident stroke cases. Of which 1,049 (71.3%) were IS, 383 (26.0%) were ICH, and 40 (2.7%) were SAH. After multivariate adjustment, hs-CRP concentrations ≥1 mg/L were associated with increased risks of all stroke (hs-CRP 1–3 mg/L: hazard ratio (HR) 1.17, 95% confidential interval (CI) 1.03–1.33; hs-CRP>3 mg/L: HR 1.25, 95% CI 1.07–1.46) and IS (hs-CRP 1–3 mg/L: HR 1.17, 95% CI 1.01–1.36; hs-CRP>3 mg/L: HR 1.33, 95% CI 1.11–1.60), but not with ICH and SAH. Subgroup analyses showed that higher hs-CRP concentration was more prone to be a risk factor for all stroke and IS in non-fatal stroke, male and hypertensive participants. CONCLUSION: We found that higher hs-CRP concentrations were associated with a higher risk of IS, particularly for non-fatal stroke, male and hypertensive subjects. In contrast, we did not observe significant associations between hs-CRP and ICH/SAH.
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spelling pubmed-41563952014-09-09 Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study Liu, Yanfang Wang, Jing Zhang, Liqun Wang, Chunxue Wu, Jianwei Zhou, Yong Gao, Xiang Wang, Anxin Wu, Shouling Zhao, Xingquan PLoS One Research Article OBJECTIVE: Previous studies have suggested that C-reactive protein (CRP) was associated with risk of stroke. There were few studies in Asian population, or on stroke subtypes other than ischemic stroke. We thus investigated the relationship between CRP and the risks of all stroke and its subtypes in a Chinese adult population. METHODS: In the current study, we included 90,517 Chinese adults free of stroke and myocardial infarction at baseline (June 2006 to October 2007) in analyses. Strokes were classified as ischemic stroke (IS), intracranial heamorrhage (ICH) and subarachnoid heamorrhage (SAH). High-sensitivity CRP (hs-CRP) were categorized into three groups: <1 mg/L, 1 to 3 mg/L, and >3 mg/L. Cox proportional hazards regression was used to calculate the association between hs-CRP concentrations and all stroke, as well as its subtypes. RESULTS: During a median follow-up time of 49 months, we documented 1,472 incident stroke cases. Of which 1,049 (71.3%) were IS, 383 (26.0%) were ICH, and 40 (2.7%) were SAH. After multivariate adjustment, hs-CRP concentrations ≥1 mg/L were associated with increased risks of all stroke (hs-CRP 1–3 mg/L: hazard ratio (HR) 1.17, 95% confidential interval (CI) 1.03–1.33; hs-CRP>3 mg/L: HR 1.25, 95% CI 1.07–1.46) and IS (hs-CRP 1–3 mg/L: HR 1.17, 95% CI 1.01–1.36; hs-CRP>3 mg/L: HR 1.33, 95% CI 1.11–1.60), but not with ICH and SAH. Subgroup analyses showed that higher hs-CRP concentration was more prone to be a risk factor for all stroke and IS in non-fatal stroke, male and hypertensive participants. CONCLUSION: We found that higher hs-CRP concentrations were associated with a higher risk of IS, particularly for non-fatal stroke, male and hypertensive subjects. In contrast, we did not observe significant associations between hs-CRP and ICH/SAH. Public Library of Science 2014-09-05 /pmc/articles/PMC4156395/ /pubmed/25191699 http://dx.doi.org/10.1371/journal.pone.0107017 Text en © 2014 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Liu, Yanfang
Wang, Jing
Zhang, Liqun
Wang, Chunxue
Wu, Jianwei
Zhou, Yong
Gao, Xiang
Wang, Anxin
Wu, Shouling
Zhao, Xingquan
Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study
title Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study
title_full Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study
title_fullStr Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study
title_full_unstemmed Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study
title_short Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study
title_sort relationship between c - reactive protein and stroke: a large prospective community based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156395/
https://www.ncbi.nlm.nih.gov/pubmed/25191699
http://dx.doi.org/10.1371/journal.pone.0107017
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