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Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease

OBJECTIVE: Importance of fatty acid components and imbalances has emerged in coronary heart disease. In this study, we analyzed fatty acids and ankle-brachial index (ABI) in a Japanese cohort. METHODS: Peripheral arterial disease (PAD) was diagnosed in 101 patients by ABI ≤0.90 and/or by angiography...

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Autores principales: Gautam, Milan, Izawa, Atsushi, Shiba, Yuji, Motoki, Hirohiko, Takeuchi, Takahiro, Okada, Ayako, Tomita, Takeshi, Miyashita, Yusuke, Koyama, Jun, Ikeda, Uichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156400/
https://www.ncbi.nlm.nih.gov/pubmed/25191963
http://dx.doi.org/10.1371/journal.pone.0107003
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author Gautam, Milan
Izawa, Atsushi
Shiba, Yuji
Motoki, Hirohiko
Takeuchi, Takahiro
Okada, Ayako
Tomita, Takeshi
Miyashita, Yusuke
Koyama, Jun
Ikeda, Uichi
author_facet Gautam, Milan
Izawa, Atsushi
Shiba, Yuji
Motoki, Hirohiko
Takeuchi, Takahiro
Okada, Ayako
Tomita, Takeshi
Miyashita, Yusuke
Koyama, Jun
Ikeda, Uichi
author_sort Gautam, Milan
collection PubMed
description OBJECTIVE: Importance of fatty acid components and imbalances has emerged in coronary heart disease. In this study, we analyzed fatty acids and ankle-brachial index (ABI) in a Japanese cohort. METHODS: Peripheral arterial disease (PAD) was diagnosed in 101 patients by ABI ≤0.90 and/or by angiography. Traditional cardiovascular risk factors and components of serum fatty acids were examined in all patients (mean age 73.2±0.9 years; 81 males), and compared with those in 373 age- and sex-matched control subjects with no evidence of PAD. RESULTS: The presence of PAD (mean ABI: 0.71±0.02) was independently associated with low levels of gamma-linolenic acid (GLA) (OR: 0.90; 95% CI: 0.85–0.96; P = 0.002), eicosapentaenoic acid∶arachidonic acid (EPA∶AA) ratio (OR: 0.38; 95% CI: 0.17–0.86; P = 0.021), and estimated glomerular filtration rate (OR: 0.97; 95% CI: 0.96–0.98; P<0.0001), and with a high hemoglobin A1c level (OR: 1.34; 95% CI: 1.06–1.69; P = 0.013). Individuals with lower levels of GLA (≤7.95 µg/mL) and a lower EPA∶AA ratio (≤0.55) had the lowest ABI (0.96±0.02, N = 90), while the highest ABI (1.12±0.01, N = 78) was observed in individuals with higher values of both GLA and EPA∶AA ratio (P<0.0001). CONCLUSION: A low level of GLA and a low EPA∶AA ratio are independently associated with the presence of PAD. Specific fatty acid abnormalities and imbalances could lead to new strategies for risk stratification and prevention in PAD patients.
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spelling pubmed-41564002014-09-09 Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease Gautam, Milan Izawa, Atsushi Shiba, Yuji Motoki, Hirohiko Takeuchi, Takahiro Okada, Ayako Tomita, Takeshi Miyashita, Yusuke Koyama, Jun Ikeda, Uichi PLoS One Research Article OBJECTIVE: Importance of fatty acid components and imbalances has emerged in coronary heart disease. In this study, we analyzed fatty acids and ankle-brachial index (ABI) in a Japanese cohort. METHODS: Peripheral arterial disease (PAD) was diagnosed in 101 patients by ABI ≤0.90 and/or by angiography. Traditional cardiovascular risk factors and components of serum fatty acids were examined in all patients (mean age 73.2±0.9 years; 81 males), and compared with those in 373 age- and sex-matched control subjects with no evidence of PAD. RESULTS: The presence of PAD (mean ABI: 0.71±0.02) was independently associated with low levels of gamma-linolenic acid (GLA) (OR: 0.90; 95% CI: 0.85–0.96; P = 0.002), eicosapentaenoic acid∶arachidonic acid (EPA∶AA) ratio (OR: 0.38; 95% CI: 0.17–0.86; P = 0.021), and estimated glomerular filtration rate (OR: 0.97; 95% CI: 0.96–0.98; P<0.0001), and with a high hemoglobin A1c level (OR: 1.34; 95% CI: 1.06–1.69; P = 0.013). Individuals with lower levels of GLA (≤7.95 µg/mL) and a lower EPA∶AA ratio (≤0.55) had the lowest ABI (0.96±0.02, N = 90), while the highest ABI (1.12±0.01, N = 78) was observed in individuals with higher values of both GLA and EPA∶AA ratio (P<0.0001). CONCLUSION: A low level of GLA and a low EPA∶AA ratio are independently associated with the presence of PAD. Specific fatty acid abnormalities and imbalances could lead to new strategies for risk stratification and prevention in PAD patients. Public Library of Science 2014-09-05 /pmc/articles/PMC4156400/ /pubmed/25191963 http://dx.doi.org/10.1371/journal.pone.0107003 Text en © 2014 Gautam et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Gautam, Milan
Izawa, Atsushi
Shiba, Yuji
Motoki, Hirohiko
Takeuchi, Takahiro
Okada, Ayako
Tomita, Takeshi
Miyashita, Yusuke
Koyama, Jun
Ikeda, Uichi
Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease
title Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease
title_full Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease
title_fullStr Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease
title_full_unstemmed Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease
title_short Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease
title_sort importance of fatty acid compositions in patients with peripheral arterial disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156400/
https://www.ncbi.nlm.nih.gov/pubmed/25191963
http://dx.doi.org/10.1371/journal.pone.0107003
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