The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon

Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (re...

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Detalles Bibliográficos
Autores principales: de Sousa, Taís Nóbrega, Kano, Flora Satiko, de Brito, Cristiana Ferreira Alves, Carvalho, Luzia Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156454/
https://www.ncbi.nlm.nih.gov/pubmed/25185002
http://dx.doi.org/10.1590/0074-0276130592
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author de Sousa, Taís Nóbrega
Kano, Flora Satiko
de Brito, Cristiana Ferreira Alves
Carvalho, Luzia Helena
author_facet de Sousa, Taís Nóbrega
Kano, Flora Satiko
de Brito, Cristiana Ferreira Alves
Carvalho, Luzia Helena
author_sort de Sousa, Taís Nóbrega
collection PubMed
description Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.
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spelling pubmed-41564542014-09-11 The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon de Sousa, Taís Nóbrega Kano, Flora Satiko de Brito, Cristiana Ferreira Alves Carvalho, Luzia Helena Mem Inst Oswaldo Cruz Articles Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania. Instituto Oswaldo Cruz, Ministério da Saúde 2014-08 /pmc/articles/PMC4156454/ /pubmed/25185002 http://dx.doi.org/10.1590/0074-0276130592 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
de Sousa, Taís Nóbrega
Kano, Flora Satiko
de Brito, Cristiana Ferreira Alves
Carvalho, Luzia Helena
The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_full The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_fullStr The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_full_unstemmed The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_short The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_sort duffy binding protein as a key target for a plasmodium vivax vaccine: lessons from the brazilian amazon
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156454/
https://www.ncbi.nlm.nih.gov/pubmed/25185002
http://dx.doi.org/10.1590/0074-0276130592
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