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Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity

We have implemented field models and performed a detailed numerical dosimetry inside our extremely-low-frequency electromagnetic bioreactor which has been successfully used in in vitro Biotechnology and Tissue Engineering researches. The numerical dosimetry permitted to map the magnetic induction fi...

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Autores principales: Mognaschi, Maria Evelina, Di Barba, Paolo, Magenes, Giovanni, Lenzi, Andrea, Naro, Fabio, Fassina, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156577/
https://www.ncbi.nlm.nih.gov/pubmed/25202652
http://dx.doi.org/10.1186/2193-1801-3-473
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author Mognaschi, Maria Evelina
Di Barba, Paolo
Magenes, Giovanni
Lenzi, Andrea
Naro, Fabio
Fassina, Lorenzo
author_facet Mognaschi, Maria Evelina
Di Barba, Paolo
Magenes, Giovanni
Lenzi, Andrea
Naro, Fabio
Fassina, Lorenzo
author_sort Mognaschi, Maria Evelina
collection PubMed
description We have implemented field models and performed a detailed numerical dosimetry inside our extremely-low-frequency electromagnetic bioreactor which has been successfully used in in vitro Biotechnology and Tissue Engineering researches. The numerical dosimetry permitted to map the magnetic induction field (maximum module equal to about 3.3 mT) and to discuss its biological effects in terms of induced electric currents and induced mechanical forces (compression and traction). So, in the frame of the tensegrity-mechanotransduction theory of Ingber, the study of these electromagnetically induced mechanical forces could be, in our opinion, a powerful tool to understand some effects of the electromagnetic stimulation whose mechanisms remain still elusive.
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spelling pubmed-41565772014-09-08 Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity Mognaschi, Maria Evelina Di Barba, Paolo Magenes, Giovanni Lenzi, Andrea Naro, Fabio Fassina, Lorenzo Springerplus Research We have implemented field models and performed a detailed numerical dosimetry inside our extremely-low-frequency electromagnetic bioreactor which has been successfully used in in vitro Biotechnology and Tissue Engineering researches. The numerical dosimetry permitted to map the magnetic induction field (maximum module equal to about 3.3 mT) and to discuss its biological effects in terms of induced electric currents and induced mechanical forces (compression and traction). So, in the frame of the tensegrity-mechanotransduction theory of Ingber, the study of these electromagnetically induced mechanical forces could be, in our opinion, a powerful tool to understand some effects of the electromagnetic stimulation whose mechanisms remain still elusive. Springer International Publishing 2014-08-27 /pmc/articles/PMC4156577/ /pubmed/25202652 http://dx.doi.org/10.1186/2193-1801-3-473 Text en © Mognaschi et al.; licensee Springer. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research
Mognaschi, Maria Evelina
Di Barba, Paolo
Magenes, Giovanni
Lenzi, Andrea
Naro, Fabio
Fassina, Lorenzo
Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity
title Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity
title_full Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity
title_fullStr Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity
title_full_unstemmed Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity
title_short Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity
title_sort field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156577/
https://www.ncbi.nlm.nih.gov/pubmed/25202652
http://dx.doi.org/10.1186/2193-1801-3-473
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