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Treatment with betablockers is associated with higher grey-scale median in carotid plaques

BACKGROUND: The presence of echolucent carotid plaques as defined by low ultrasound grey-scale median (GSM) is associated with a higher risk of stroke and myocardial infarction. Betablockers have shown possible anti-atherosclerotic effects. The aim of the present study was to determine if there is a...

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Autores principales: Asciutto, Giuseppe, Dias, Nuno V, Persson, Ana, Nilsson, Jan, Gonçalves, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156604/
https://www.ncbi.nlm.nih.gov/pubmed/25175336
http://dx.doi.org/10.1186/1471-2261-14-111
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author Asciutto, Giuseppe
Dias, Nuno V
Persson, Ana
Nilsson, Jan
Gonçalves, Isabel
author_facet Asciutto, Giuseppe
Dias, Nuno V
Persson, Ana
Nilsson, Jan
Gonçalves, Isabel
author_sort Asciutto, Giuseppe
collection PubMed
description BACKGROUND: The presence of echolucent carotid plaques as defined by low ultrasound grey-scale median (GSM) is associated with a higher risk of stroke and myocardial infarction. Betablockers have shown possible anti-atherosclerotic effects. The aim of the present study was to determine if there is an association between carotid plaque GSM and treatment with betablockers. METHODS: The GSM of the carotid plaques of 350 patients who underwent carotid endarterectomy (CEA) for asymptomatic (n = 113) or symptomatic (n = 237) carotid disease was measured. Patients were divided in two groups based on the absence/presence of an on-going long-term (i.e. at least 6 months) oral treatment with betablockers at the time of CEA. RESULTS: The prevalence and type of preoperative neurological symptoms were similar in the two groups. Patients with betablockers had more frequently arterial hypertension (P < .0001), diabetes (P = .035) and a higher BMI (P = .0004), while patients without betablockers were most frequently smokers (P = .017). Patients with betablockers revealed to have higher GSM (37.79 ± 25 vs 32.61 ± 23.50 P = .036). Echogenic plaques (i.e. with GSM > 30) showed to be more frequent in patients with betablockers also after correction for age, gender, the occurrence of preoperative symptoms, diabetes, hypertension, smoking and statins use (P = .024). CONCLUSIONS: These results suggest the use of standardized ultrasound techniques as an important tool in evaluating the effect of anti-atherosclerotic medications and underline the need of.further prospective randomized studies on larger patient cohorts in order to confirm these results.
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spelling pubmed-41566042014-09-07 Treatment with betablockers is associated with higher grey-scale median in carotid plaques Asciutto, Giuseppe Dias, Nuno V Persson, Ana Nilsson, Jan Gonçalves, Isabel BMC Cardiovasc Disord Research Article BACKGROUND: The presence of echolucent carotid plaques as defined by low ultrasound grey-scale median (GSM) is associated with a higher risk of stroke and myocardial infarction. Betablockers have shown possible anti-atherosclerotic effects. The aim of the present study was to determine if there is an association between carotid plaque GSM and treatment with betablockers. METHODS: The GSM of the carotid plaques of 350 patients who underwent carotid endarterectomy (CEA) for asymptomatic (n = 113) or symptomatic (n = 237) carotid disease was measured. Patients were divided in two groups based on the absence/presence of an on-going long-term (i.e. at least 6 months) oral treatment with betablockers at the time of CEA. RESULTS: The prevalence and type of preoperative neurological symptoms were similar in the two groups. Patients with betablockers had more frequently arterial hypertension (P < .0001), diabetes (P = .035) and a higher BMI (P = .0004), while patients without betablockers were most frequently smokers (P = .017). Patients with betablockers revealed to have higher GSM (37.79 ± 25 vs 32.61 ± 23.50 P = .036). Echogenic plaques (i.e. with GSM > 30) showed to be more frequent in patients with betablockers also after correction for age, gender, the occurrence of preoperative symptoms, diabetes, hypertension, smoking and statins use (P = .024). CONCLUSIONS: These results suggest the use of standardized ultrasound techniques as an important tool in evaluating the effect of anti-atherosclerotic medications and underline the need of.further prospective randomized studies on larger patient cohorts in order to confirm these results. BioMed Central 2014-08-30 /pmc/articles/PMC4156604/ /pubmed/25175336 http://dx.doi.org/10.1186/1471-2261-14-111 Text en © Asciutto et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Asciutto, Giuseppe
Dias, Nuno V
Persson, Ana
Nilsson, Jan
Gonçalves, Isabel
Treatment with betablockers is associated with higher grey-scale median in carotid plaques
title Treatment with betablockers is associated with higher grey-scale median in carotid plaques
title_full Treatment with betablockers is associated with higher grey-scale median in carotid plaques
title_fullStr Treatment with betablockers is associated with higher grey-scale median in carotid plaques
title_full_unstemmed Treatment with betablockers is associated with higher grey-scale median in carotid plaques
title_short Treatment with betablockers is associated with higher grey-scale median in carotid plaques
title_sort treatment with betablockers is associated with higher grey-scale median in carotid plaques
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156604/
https://www.ncbi.nlm.nih.gov/pubmed/25175336
http://dx.doi.org/10.1186/1471-2261-14-111
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