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Notable epigenetic role of hyperhomocysteinemia in atherogenesis

Atherosclerosis is associated with multiple genetic and modifiable risk factors. There is an increasing body of evidences to indicate that epigenetic mechanisms also play an essential role in atherogenesis by influencing gene expression. Homocysteine is a sulfur-containing amino acid formed during m...

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Detalles Bibliográficos
Autores principales: Zhou, Shuyu, Zhang, Zhizhong, Xu, Gelin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156629/
https://www.ncbi.nlm.nih.gov/pubmed/25142226
http://dx.doi.org/10.1186/1476-511X-13-134
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author Zhou, Shuyu
Zhang, Zhizhong
Xu, Gelin
author_facet Zhou, Shuyu
Zhang, Zhizhong
Xu, Gelin
author_sort Zhou, Shuyu
collection PubMed
description Atherosclerosis is associated with multiple genetic and modifiable risk factors. There is an increasing body of evidences to indicate that epigenetic mechanisms also play an essential role in atherogenesis by influencing gene expression. Homocysteine is a sulfur-containing amino acid formed during methionine metabolism. Elevated plasma level of homocysteine is generally termed as hyperhomocysteinemia. As a potential risk factor for cardiovascular diseases, hyperhomocysteinemia may initiate or motivate atherogenesis by modification of DNA methylation. The underlying epigenetic mechanism is still unclear with controversial findings. This review focuses on epigenetic involvement and mechanisms of hyperhomocysteinemia in atherogenesis. Considering the potential beneficial effects of anti-homocysteinemia treatments in preventing atherosclerosis, further studies on the role of hyperhomocysteinemia in atherogenesis are warranted.
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spelling pubmed-41566292014-09-07 Notable epigenetic role of hyperhomocysteinemia in atherogenesis Zhou, Shuyu Zhang, Zhizhong Xu, Gelin Lipids Health Dis Review Atherosclerosis is associated with multiple genetic and modifiable risk factors. There is an increasing body of evidences to indicate that epigenetic mechanisms also play an essential role in atherogenesis by influencing gene expression. Homocysteine is a sulfur-containing amino acid formed during methionine metabolism. Elevated plasma level of homocysteine is generally termed as hyperhomocysteinemia. As a potential risk factor for cardiovascular diseases, hyperhomocysteinemia may initiate or motivate atherogenesis by modification of DNA methylation. The underlying epigenetic mechanism is still unclear with controversial findings. This review focuses on epigenetic involvement and mechanisms of hyperhomocysteinemia in atherogenesis. Considering the potential beneficial effects of anti-homocysteinemia treatments in preventing atherosclerosis, further studies on the role of hyperhomocysteinemia in atherogenesis are warranted. BioMed Central 2014-08-21 /pmc/articles/PMC4156629/ /pubmed/25142226 http://dx.doi.org/10.1186/1476-511X-13-134 Text en © Zhou et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhou, Shuyu
Zhang, Zhizhong
Xu, Gelin
Notable epigenetic role of hyperhomocysteinemia in atherogenesis
title Notable epigenetic role of hyperhomocysteinemia in atherogenesis
title_full Notable epigenetic role of hyperhomocysteinemia in atherogenesis
title_fullStr Notable epigenetic role of hyperhomocysteinemia in atherogenesis
title_full_unstemmed Notable epigenetic role of hyperhomocysteinemia in atherogenesis
title_short Notable epigenetic role of hyperhomocysteinemia in atherogenesis
title_sort notable epigenetic role of hyperhomocysteinemia in atherogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156629/
https://www.ncbi.nlm.nih.gov/pubmed/25142226
http://dx.doi.org/10.1186/1476-511X-13-134
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