Programmable Nanoscaffolds That Control Ligand Display to a G-Protein-Coupled Receptor in Membranes To Allow Dissection of Multivalent Effects

[Image: see text] A programmable ligand display system can be used to dissect the multivalent effects of ligand binding to a membrane receptor. An antagonist of the A(2A) adenosine receptor, a G-protein-coupled receptor that is a drug target for neurodegenerative conditions, was displayed in 35 diff...

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Autores principales: Dix, Andrew V., Moss, Steven M., Phan, Khai, Hoppe, Travis, Paoletta, Silvia, Kozma, Eszter, Gao, Zhan-Guo, Durell, Stewart R., Jacobson, Kenneth A., Appella, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156868/
https://www.ncbi.nlm.nih.gov/pubmed/25116377
http://dx.doi.org/10.1021/ja504288s

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