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Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation

CRISPR drives prokaryotic adaptation to invasive nucleic acids such as phages and plasmids using an RNA-mediated interference mechanism. Interference in Type I CRISPR-Cas systems requires a targeting Cascade complex and a degradation machine Cas3, which contains both nuclease and helicase activities...

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Detalles Bibliográficos
Autores principales:	Huo, Yanwu, Nam, Ki Hyun, Ding, Fang, Lee, Heejin, Wu, Lijie, Xiao, Yibei, Farchione, F. Daniel, Zhou, Sharleen, Rajashankar, Raj, Kurinov, Igor, Zhang, Rongguang, Ke, Ailong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156918/ https://www.ncbi.nlm.nih.gov/pubmed/25132177 http://dx.doi.org/10.1038/nsmb.2875

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