Cargando…

Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum

BACKGROUND: COPD patients have increased numbers of macrophages and neutrophils in the lungs. Interleukin-6 (IL-6) trans-signaling via its soluble receptor sIL-6R, governs the influx of innate immune cells to inflammatory foci through regulation of the chemokine CCL3. We hypothesized that there woul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ravi, Arjun K, Khurana, Shruti, Lemon, Jonathan, Plumb, Jonathan, Booth, George, Healy, Louise, Catley, Matthew, Vestbo, Jørgen, Singh, Dave
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156958/ https://www.ncbi.nlm.nih.gov/pubmed/25183374 http://dx.doi.org/10.1186/s12931-014-0103-4

Ejemplares similares

COPD monocytes demonstrate impaired migratory ability
por: Ravi, Arjun K, et al.
Publicado: (2017)

The effects of corticosteroids on COPD lung macrophages: a pooled analysis
por: Higham, Andrew, et al.
Publicado: (2015)

The repeatability of interleukin-6, tumor necrosis factor-α, and C-reactive protein in COPD patients over one year
por: Kolsum, Umme, et al.
Publicado: (2009)

The Effect of Fatigue and Fatigue Intensity on Exercise Tolerance in Moderate COPD
por: Al-shair, Khaled, et al.
Publicado: (2016)

COVID-19 and COPD: a narrative review of the basic science and clinical outcomes
por: Higham, Andrew, et al.
Publicado: (2020)

Blood and sputum eosinophils in COPD; relationship with bacterial load
por: Kolsum, Umme, et al.
Publicado: (2017)

Validation of Sputum Biomarker Immunoassays and Cytokine Expression Profiles in COPD
por: Mulvanny, Alex, et al.
Publicado: (2022)

Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients
por: Urbanowicz, Richard A, et al.
Publicado: (2010)

Prevention of COPD exacerbations: medications and other controversies
por: Vestbo, Jørgen, et al.
Publicado: (2015)

COPD phenotype description using principal components analysis
por: Roy, Kay, et al.
Publicado: (2009)

Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts
por: Beech, Augusta, et al.
Publicado: (2022)

Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study
por: Singh, Dave, et al.
Publicado: (2010)

Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD
por: Al-shair, Khaled, et al.
Publicado: (2011)

Bacteria and sputum inflammatory cell counts; a COPD cohort analysis
por: Beech, Augusta S., et al.
Publicado: (2020)

The sputum microbiome is distinct between COPD and health, independent of smoking history
por: Haldar, Koirobi, et al.
Publicado: (2020)

Sputum microbiology predicts health status in COPD
por: Braeken, Dionne CW, et al.
Publicado: (2016)

Altered Gene Expression in Blood and Sputum in COPD Frequent Exacerbators in the ECLIPSE Cohort
por: Singh, Dave, et al.
Publicado: (2014)

Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells
por: Grundy, Seamus, et al.
Publicado: (2016)

Down Regulation of T Cell Receptor Expression in COPD Pulmonary CD8 Cells
por: Grundy, Seamus, et al.
Publicado: (2013)

Coronary heart disease and heart failure in asthma, COPD and asthma-COPD overlap
por: Ingebrigtsen, Truls Sylvan, et al.
Publicado: (2020)

Sputum Streptococcus pneumoniae is reduced in COPD following treatment with benralizumab
por: George, Leena, et al.
Publicado: (2019)

The global impact of Aspergillus infection on COPD
por: Hammond, Emily E., et al.
Publicado: (2020)

Sputum cell count: biomarkers in the differentiation of asthma, COPD and asthma–COPD overlap
por: Gao, Jie, et al.
Publicado: (2017)

The Manchester Respiratory-related Sleep Symptoms scale for patients with COPD: development and validation
por: Khan, Naimat, et al.
Publicado: (2018)

COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type‐2 and PDE4 gene expression in sputum
por: Singh, Dave, et al.
Publicado: (2020)

Characterization of sputum biomarkers for asthma–COPD overlap syndrome
por: Gao, Jing, et al.
Publicado: (2016)

Comparison of inflammatory markers in induced and spontaneous sputum in a cohort of COPD patients
por: Tangedal, Solveig, et al.
Publicado: (2014)

Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
por: Kolsum, Umme, et al.
Publicado: (2017)

A systematic evaluation of the diagnostic criteria for COPD and exacerbations used in randomised controlled trials on the management of COPD exacerbations
por: Mathioudakis, Alexander G., et al.
Publicado: (2019)

The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils
por: Ditz, Benedikt, et al.
Publicado: (2021)

Long-term survival for COPD patients receiving noninvasive ventilation for acute respiratory failure
por: Titlestad, Ingrid L, et al.
Publicado: (2013)

COPD sputum eosinophils: relationship to blood eosinophils and the effect of inhaled PDE4 inhibition
por: Singh, Dave, et al.
Publicado: (2020)

Triple therapy in COPD: new evidence with the extrafine fixed combination of beclomethasone dipropionate, formoterol fumarate, and glycopyrronium bromide
por: Singh, Dave, et al.
Publicado: (2017)

Assessment of bacterial exposure on phagocytic capability and surface marker expression of sputum macrophages and neutrophils in COPD patients
por: Lea, Simon, et al.
Publicado: (2021)

Dyspnea assessment and adverse events during sputum induction in COPD
por: Makris, Demosthenes, et al.
Publicado: (2006)

Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients
por: Harju, Terttu H, et al.
Publicado: (2007)

Anxiety and depression in COPD patients and correlation with sputum and BAL cytology
por: Tetikkurt, Cuneyt, et al.
Publicado: (2011)

Sputum Bacterial and Fungal Dynamics during Exacerbations of Severe COPD
por: Su, Jin, et al.
Publicado: (2015)

Bacterial flora in the sputum and comorbidity in patients with acute exacerbations of COPD
por: Boixeda, Ramon, et al.
Publicado: (2015)

Microparticles in sputum of COPD patients: a potential biomarker of the disease?
por: Lacedonia, Donato, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gho1rcrjv6nj3thasqte877p8u