Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAF(V600E) inhibition

BACKGROUND: Advances in melanoma treatment through targeted inhibition of oncogenic BRAF are limited owing to the development of acquired resistance. The involvement of BRAF(V600E) in metabolic reprogramming of melanoma cells provides a rationale for co-targeting metabolism as a therapeutic approach...

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Detalles Bibliográficos
Autores principales: Abildgaard, Cecilie, Dahl, Christina, Basse, Astrid L, Ma, Tao, Guldberg, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156963/
https://www.ncbi.nlm.nih.gov/pubmed/25182332
http://dx.doi.org/10.1186/s12967-014-0247-5

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