Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study. All children were genotyped for variants of...

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Autores principales: Łuczyński, Włodzimierz, Fendler, Wojciech, Ramatowska, Anna, Szypowska, Agnieszka, Szadkowska, Agnieszka, Młynarski, Wojciech, Chumiecki, Miron, Jarosz-Chobot, Przemysława, Chrzanowska, Joanna, Noczyńska, Anna, Brandt, Agnieszka, Myśliwiec, Małgorzata, Głowińska-Olszewska, Barbara, Bernatowicz, Paweł, Kowalczuk, Oksana, Bossowski, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156980/
https://www.ncbi.nlm.nih.gov/pubmed/25214838
http://dx.doi.org/10.1155/2014/630712
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author Łuczyński, Włodzimierz
Fendler, Wojciech
Ramatowska, Anna
Szypowska, Agnieszka
Szadkowska, Agnieszka
Młynarski, Wojciech
Chumiecki, Miron
Jarosz-Chobot, Przemysława
Chrzanowska, Joanna
Noczyńska, Anna
Brandt, Agnieszka
Myśliwiec, Małgorzata
Głowińska-Olszewska, Barbara
Bernatowicz, Paweł
Kowalczuk, Oksana
Bossowski, Artur
author_facet Łuczyński, Włodzimierz
Fendler, Wojciech
Ramatowska, Anna
Szypowska, Agnieszka
Szadkowska, Agnieszka
Młynarski, Wojciech
Chumiecki, Miron
Jarosz-Chobot, Przemysława
Chrzanowska, Joanna
Noczyńska, Anna
Brandt, Agnieszka
Myśliwiec, Małgorzata
Głowińska-Olszewska, Barbara
Bernatowicz, Paweł
Kowalczuk, Oksana
Bossowski, Artur
author_sort Łuczyński, Włodzimierz
collection PubMed
description The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P = 0.0003), poor metabolic control (P = 0.0001), and carriage of the A allele of the FTO rs9939609 gene (P = 0.02). Conclusion. Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161).
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spelling pubmed-41569802014-09-11 Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity Łuczyński, Włodzimierz Fendler, Wojciech Ramatowska, Anna Szypowska, Agnieszka Szadkowska, Agnieszka Młynarski, Wojciech Chumiecki, Miron Jarosz-Chobot, Przemysława Chrzanowska, Joanna Noczyńska, Anna Brandt, Agnieszka Myśliwiec, Małgorzata Głowińska-Olszewska, Barbara Bernatowicz, Paweł Kowalczuk, Oksana Bossowski, Artur Int J Endocrinol Research Article The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P = 0.0003), poor metabolic control (P = 0.0001), and carriage of the A allele of the FTO rs9939609 gene (P = 0.02). Conclusion. Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161). Hindawi Publishing Corporation 2014 2014-08-19 /pmc/articles/PMC4156980/ /pubmed/25214838 http://dx.doi.org/10.1155/2014/630712 Text en Copyright © 2014 Włodzimierz Łuczyński et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Łuczyński, Włodzimierz
Fendler, Wojciech
Ramatowska, Anna
Szypowska, Agnieszka
Szadkowska, Agnieszka
Młynarski, Wojciech
Chumiecki, Miron
Jarosz-Chobot, Przemysława
Chrzanowska, Joanna
Noczyńska, Anna
Brandt, Agnieszka
Myśliwiec, Małgorzata
Głowińska-Olszewska, Barbara
Bernatowicz, Paweł
Kowalczuk, Oksana
Bossowski, Artur
Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_full Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_fullStr Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_full_unstemmed Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_short Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_sort polymorphism of the fto gene influences body weight in children with type 1 diabetes without severe obesity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156980/
https://www.ncbi.nlm.nih.gov/pubmed/25214838
http://dx.doi.org/10.1155/2014/630712
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