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Hypomethylation at the Regulatory T Cell–Specific Demethylated Region in CD25(hi) T Cells Is Decoupled from FOXP3 Expression at the Inflamed Site in Childhood Arthritis

The maintenance of FOXP3 expression in CD25(hi) regulatory T cells (Tregs) is crucial to the control of inflammation and essential for successful Treg transfer therapies. Coexpression of CD25 and FOXP3 in combination with a hypomethylated region within the FOXP3 gene, called the Treg-specific demeth...

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Detalles Bibliográficos
Autores principales:	Bending, David, Pesenacker, Anne M., Ursu, Simona, Wu, Qiong, Lom, Hannah, Thirugnanabalan, Balathas, Wedderburn, Lucy R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2014
Materias:	Clinical and Human Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157061/ https://www.ncbi.nlm.nih.gov/pubmed/25092890 http://dx.doi.org/10.4049/jimmunol.1400599

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