Cargando…

Characterization of a monoclonal antibody to a novel glycan-dependent epitope in the V1/V2 domain of the HIV-1 envelope protein, gp120

Recent studies have described several broadly neutralizing monoclonal antibodies (bN-mAbs) that recognize glycan-dependent epitopes (GDEs) in the HIV-1 envelope protein, gp120. These were recovered from HIV-1 infected subjects, and several (e.g., PG9, PG16, CH01, CH03) target glycans in the first an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Doran, Rachel C., Morales, Javier F., To, Briana, Morin, Trevor J., Theolis Jr., Richard, O’Rourke, Sara M., Yu, Bin, Mesa, Kathryn A., Berman, Phillip W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157072/ https://www.ncbi.nlm.nih.gov/pubmed/25016576 http://dx.doi.org/10.1016/j.molimm.2014.06.025

Ejemplares similares

Glycans Flanking the Hypervariable Connecting Peptide between the A and B Strands of the V1/V2 Domain of HIV-1 gp120 Confer Resistance to Antibodies That Neutralize CRF01_AE Viruses
por: O’Rourke, Sara M., et al.
Publicado: (2015)

Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies
por: Doran, Rachel C., et al.
Publicado: (2018)

Extensive glycoform heterogeneity in the gp120 envelope proteins used in the RV144 trial
por: Yu, B, et al.
Publicado: (2012)

Antigen processing sites in gp120 are conserved across HIV virus clades
por: Yu, B, et al.
Publicado: (2012)

Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies
por: Hutchinson, Jennie M., et al.
Publicado: (2019)

Improving immunogenicity of HIV-1 envelope gp120 by glycan removal and immune complex formation
por: Kumar, R, et al.
Publicado: (2012)

Monoclonal Antibodies to the V2 Domain of MN-rgp120: Fine Mapping of Epitopes and Inhibition of α4β7 Binding
por: Nakamura, Gerald R., et al.
Publicado: (2012)

Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity
por: Drummer, Heidi E., et al.
Publicado: (2013)

Development of a Stable MGAT1(−) CHO Cell Line to Produce Clade C gp120 With Improved Binding to Broadly Neutralizing Antibodies
por: Doran, Rachel C., et al.
Publicado: (2018)

Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies
por: Rusert, Peter, et al.
Publicado: (2011)

Structural Dynamics of HIV-1 Envelope Gp120 Outer Domain with V3 Loop
por: Yokoyama, Masaru, et al.
Publicado: (2012)

The Influence of N-Linked Glycans on the Molecular Dynamics of the HIV-1 gp120 V3 Loop
por: Wood, Natasha T., et al.
Publicado: (2013)

Effect of Glycosylation on an Immunodominant Region in the V1V2 Variable Domain of the HIV-1 Envelope gp120 Protein
por: Tian, Jianhui, et al.
Publicado: (2016)

Transforming epitope-specific gp120 monomer-based probes into immunogens with N-linked glycan masking
por: Chuang, G, et al.
Publicado: (2012)

Glycan shield of the ebolavirus envelope glycoprotein GP
por: Peng, Weiwei, et al.
Publicado: (2022)

Glycoform and Net Charge Heterogeneity in gp120 Immunogens Used in HIV Vaccine Trials
por: Yu, Bin, et al.
Publicado: (2012)

Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41
por: Sanders, Rogier W, et al.
Publicado: (2004)

Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses
por: Bowder, Dane, et al.
Publicado: (2018)

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions
por: Seabright, Gemma E., et al.
Publicado: (2020)

Structural definition of a conserved neutralization epitope on HIV-1 gp120
por: Zhou, Tongqing, et al.
Publicado: (2007)

Patterns of conserved gp120 epitope presentation on attached HIV-1 virions
por: Mengistu, Meron, et al.
Publicado: (2017)

Myomedin replicas of gp120 V3 loop glycan epitopes recognized by PGT121 and PGT126 antibodies as non-cognate antigens for stimulation of HIV-1 broadly neutralizing antibodies
por: Daniel Lišková, Veronika, et al.
Publicado: (2022)

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
por: Kong, Leopold, et al.
Publicado: (2013)

Differential glycosylation of envelope gp120 affects reactivity with HIV-1 specific antibodies
por: Czernekova, Lydie, et al.
Publicado: (2014)

HIV-1 gp120 envelope glycoprotein determinants for cytokine burst in human monocytes
por: Levast, Benoît, et al.
Publicado: (2017)

Broad-Spectrum Inhibition of HIV-1 by a Monoclonal Antibody Directed against a gp120-Induced Epitope of CD4
por: Burastero, Samuele E., et al.
Publicado: (2011)

Deletion of the Highly Conserved N-Glycan at Asn260 of HIV-1 gp120 Affects Folding and Lysosomal Degradation of gp120, and Results in Loss of Viral Infectivity
por: Mathys, Leen, et al.
Publicado: (2014)

A Twin-Cysteine Motif in the V2 Region of gp120 Is Associated with SIV Envelope Trimer Stabilization
por: Bohl, Christopher, et al.
Publicado: (2013)

Structural Plasticity and Conformational Transitions of HIV Envelope Glycoprotein gp120
por: Korkut, Anil, et al.
Publicado: (2012)

HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell
por: Valentín-Guillama, Gabriel, et al.
Publicado: (2018)

Correction: Deletion of the Highly Conserved N-Glycan at Asn260 of HIV-1 gp120 Affects Folding and Lysosomal Degradation of gp120, and Results in Loss of Viral Infectivity
Publicado: (2014)

Several N-Glycans on the HIV Envelope Glycoprotein gp120 Preferentially Locate Near Disulphide Bridges and Are Required for Efficient Infectivity and Virus Transmission
por: Mathys, Leen, et al.
Publicado: (2015)

Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers
por: de Taeye, Steven W., et al.
Publicado: (2018)

Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomer
Publicado: (1995)

Indirect Detection of an Epitope-Specific Response to HIV-1 gp120 Immunization in Human Subjects
por: Shmelkov, Evgeny, et al.
Publicado: (2011)

A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques
por: Jones, Andrew T., et al.
Publicado: (2018)

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120
por: Yolitz, Jason, et al.
Publicado: (2018)

HIV-1 envelope trimer elicits higher neutralizing antibody responses than monomeric gp120
por: Kovacs, JM, et al.
Publicado: (2012)

Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120
por: Meier, Julia, et al.
Publicado: (2012)

Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins
por: Herschhorn, Alon, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9a4va8jo4mvh0oilbf4vnkgpka