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Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans
The nature of the oral cavity and host behaviors has mandated that the oral microbiota evolve mechanisms for coping with environmental fluctuations, especially changes in the type and availability of carbohydrates. In the case of human dental caries, the presence of excess carbohydrates is often res...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Co-Action Publishing
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157138/ https://www.ncbi.nlm.nih.gov/pubmed/25317251 http://dx.doi.org/10.3402/jom.v6.24878 |
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author | Moye, Zachary D. Zeng, Lin Burne, Robert A. |
author_facet | Moye, Zachary D. Zeng, Lin Burne, Robert A. |
author_sort | Moye, Zachary D. |
collection | PubMed |
description | The nature of the oral cavity and host behaviors has mandated that the oral microbiota evolve mechanisms for coping with environmental fluctuations, especially changes in the type and availability of carbohydrates. In the case of human dental caries, the presence of excess carbohydrates is often responsible for altering the local environment to be more favorable for species associated with the initiation and progression of disease, including Streptococcus mutans. Some of the earliest endeavors to understand how cariogenic species respond to environmental perturbations were carried out using chemostat cultivation, which provides fine control over culture conditions and bacterial behaviors. The development of genome-scale methodologies has allowed for the combination of sophisticated cultivation technologies with genome-level analysis to more thoroughly probe how bacterial pathogens respond to environmental stimuli. Recent investigations in S. mutans and other closely related streptococci have begun to reveal that carbohydrate metabolism can drastically impact pathogenic potential and highlight the important influence that nutrient acquisition has on the success of pathogens; inside and outside of the oral cavity. Collectively, research into pathogenic streptococci, which have evolved in close association with the human host, has begun to unveil the essential nature of careful orchestration of carbohydrate acquisition and catabolism to allow the organisms to persist and, when conditions allow, initiate or worsen disease. |
format | Online Article Text |
id | pubmed-4157138 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-41571382014-10-14 Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans Moye, Zachary D. Zeng, Lin Burne, Robert A. J Oral Microbiol Review Article The nature of the oral cavity and host behaviors has mandated that the oral microbiota evolve mechanisms for coping with environmental fluctuations, especially changes in the type and availability of carbohydrates. In the case of human dental caries, the presence of excess carbohydrates is often responsible for altering the local environment to be more favorable for species associated with the initiation and progression of disease, including Streptococcus mutans. Some of the earliest endeavors to understand how cariogenic species respond to environmental perturbations were carried out using chemostat cultivation, which provides fine control over culture conditions and bacterial behaviors. The development of genome-scale methodologies has allowed for the combination of sophisticated cultivation technologies with genome-level analysis to more thoroughly probe how bacterial pathogens respond to environmental stimuli. Recent investigations in S. mutans and other closely related streptococci have begun to reveal that carbohydrate metabolism can drastically impact pathogenic potential and highlight the important influence that nutrient acquisition has on the success of pathogens; inside and outside of the oral cavity. Collectively, research into pathogenic streptococci, which have evolved in close association with the human host, has begun to unveil the essential nature of careful orchestration of carbohydrate acquisition and catabolism to allow the organisms to persist and, when conditions allow, initiate or worsen disease. Co-Action Publishing 2014-09-05 /pmc/articles/PMC4157138/ /pubmed/25317251 http://dx.doi.org/10.3402/jom.v6.24878 Text en © 2014 Zachary D. Moye et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Moye, Zachary D. Zeng, Lin Burne, Robert A. Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans |
title | Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans
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title_full | Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans
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title_fullStr | Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans
|
title_full_unstemmed | Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans
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title_short | Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans
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title_sort | fueling the caries process: carbohydrate metabolism and gene regulation by streptococcus mutans |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157138/ https://www.ncbi.nlm.nih.gov/pubmed/25317251 http://dx.doi.org/10.3402/jom.v6.24878 |
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