Granularity in granular cell ameloblastoma

Granular cell ameloblastoma (GCA) is one of the rare histological variants of ameloblastoma (1.5-3.5%), identified by Krompechner in 1918 and is diagnosed by the characteristic presence of granular cells. These granular cells are seen in several physiological and pathological conditions and the gran...

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Detalles Bibliográficos
Autores principales: Yamunadevi, Andamuthu, Madhushankari, G. S., Selvamani, Manickam, Basandi, Praveen S., Yoithapprabhunath, Thukanayyakanpalayam Ragunathan, Ganapathy, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Dental Science - Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157257/
https://www.ncbi.nlm.nih.gov/pubmed/25210361
http://dx.doi.org/10.4103/0975-7406.137253
Descripción
Sumario:Granular cell ameloblastoma (GCA) is one of the rare histological variants of ameloblastoma (1.5-3.5%), identified by Krompechner in 1918 and is diagnosed by the characteristic presence of granular cells. These granular cells are seen in several physiological and pathological conditions and the granularity in GCA is due to lysosomal aggregates. This review is about the clinical features, histopathological features and differential diagnosis of GCA and also adds the theories for occurrence of granularity, electron microscopic findings, cell signaling pathways and immunohistochemistry findings related to these granular cells in GCA.

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