Synthesis and Biological Evaluation of Macrocyclized Betulin Derivatives as a Novel Class of Anti-HIV-1 Maturation Inhibitors

A macrocycle provides diverse functionality and stereochemical complexity in a conformationally preorganized ring structure, and it occupies a unique chemical space in drug discovery. However, the synthetic challenge to access this structural class is high and hinders the exploration of macrocycles....

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Detalles Bibliográficos
Autores principales: Tang, Jun, Jones, Stacey A., Jeffery, Jerry L., Miranda, Sonia R., Galardi, Cristin M., Irlbeck, David M., Brown, Kevin W., McDanal, Charlene B., Han, Nianhe, Gao, Daxin, Wu, Yongyong, Shen, Bin, Liu, Chunyu, Xi, Caiming, Yang, Heping, Li, Rui, Yu, Yajun, Sun, Yufei, Jin, Zhimin, Wang, Erjuan, Johns, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157350/
https://www.ncbi.nlm.nih.gov/pubmed/25250097
http://dx.doi.org/10.2174/1874104501408010023

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