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(19)F NMR spectroscopy monitors ligand binding to recombinantly fluorine-labelled b′x from human protein disulphide isomerase (hPDI)

We report a protein-observe (19)F NMR-based ligand titration binding study of human PDI b′x with Δ-somatostatin that also emphasises the need to optimise recombinant protein fluorination when using 5- or 6-fluoroindole. This study highlights a recombinant preference for 5-fluoroindole over 6-fluoroi...

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Detalles Bibliográficos
Autores principales:	Curtis-Marof, Rose, Doko, Denisa, Rowe, Michelle L., Richards, Kirsty L., Williamson, Richard A., Howard, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2014
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157668/ https://www.ncbi.nlm.nih.gov/pubmed/24796794 http://dx.doi.org/10.1039/c4ob00699b

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