Intrinsic Differences between Oral and Skin Keratinocytes

Keratinocytes cover both the skin and some oral mucosa, but the morphology of each tissue and the behavior of the keratinocytes from these two sites are different. One significant dissimilarity between the two sites is the response to injury. Oral mucosal wounds heal faster and with less inflammatio...

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Detalles Bibliográficos
Autores principales: Turabelidze, Anna, Guo, Shujuan, Chung, Allison Yen, Chen, Lin, Dai, Yang, Marucha, Phillip T., DiPietro, Luisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157746/
https://www.ncbi.nlm.nih.gov/pubmed/25198578
http://dx.doi.org/10.1371/journal.pone.0101480
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author Turabelidze, Anna
Guo, Shujuan
Chung, Allison Yen
Chen, Lin
Dai, Yang
Marucha, Phillip T.
DiPietro, Luisa A.
author_facet Turabelidze, Anna
Guo, Shujuan
Chung, Allison Yen
Chen, Lin
Dai, Yang
Marucha, Phillip T.
DiPietro, Luisa A.
author_sort Turabelidze, Anna
collection PubMed
description Keratinocytes cover both the skin and some oral mucosa, but the morphology of each tissue and the behavior of the keratinocytes from these two sites are different. One significant dissimilarity between the two sites is the response to injury. Oral mucosal wounds heal faster and with less inflammation than equivalent cutaneous wounds. We hypothesized that oral and skin keratinocytes might have intrinsic differences at baseline as well as in the response to injury, and that such differences would be reflected in gene expression profiles.
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spelling pubmed-41577462014-09-09 Intrinsic Differences between Oral and Skin Keratinocytes Turabelidze, Anna Guo, Shujuan Chung, Allison Yen Chen, Lin Dai, Yang Marucha, Phillip T. DiPietro, Luisa A. PLoS One Research Article Keratinocytes cover both the skin and some oral mucosa, but the morphology of each tissue and the behavior of the keratinocytes from these two sites are different. One significant dissimilarity between the two sites is the response to injury. Oral mucosal wounds heal faster and with less inflammation than equivalent cutaneous wounds. We hypothesized that oral and skin keratinocytes might have intrinsic differences at baseline as well as in the response to injury, and that such differences would be reflected in gene expression profiles. Public Library of Science 2014-09-08 /pmc/articles/PMC4157746/ /pubmed/25198578 http://dx.doi.org/10.1371/journal.pone.0101480 Text en © 2014 Turabelidze et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Turabelidze, Anna
Guo, Shujuan
Chung, Allison Yen
Chen, Lin
Dai, Yang
Marucha, Phillip T.
DiPietro, Luisa A.
Intrinsic Differences between Oral and Skin Keratinocytes
title Intrinsic Differences between Oral and Skin Keratinocytes
title_full Intrinsic Differences between Oral and Skin Keratinocytes
title_fullStr Intrinsic Differences between Oral and Skin Keratinocytes
title_full_unstemmed Intrinsic Differences between Oral and Skin Keratinocytes
title_short Intrinsic Differences between Oral and Skin Keratinocytes
title_sort intrinsic differences between oral and skin keratinocytes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157746/
https://www.ncbi.nlm.nih.gov/pubmed/25198578
http://dx.doi.org/10.1371/journal.pone.0101480
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