Multivalent Antiviral XTEN–Peptide Conjugates with Long in Vivo Half-Life and Enhanced Solubility

[Image: see text] XTENs are unstructured, nonrepetitive protein polymers designed to prolong the in vivo half-life of pharmaceuticals by introducing a bulking effect similar to that of poly(ethylene glycol). While XTEN can be expressed as a recombinant fusion protein with bioactive proteins and pept...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Sheng, Song, Michael, Sim, Bee-Cheng, Gu, Chen, Podust, Vladimir N., Wang, Chia-Wei, McLaughlin, Bryant, Shah, Trishul P, Lax, Rodney, Gast, Rainer, Sharan, Rahul, Vasek, Arthur, Hartman, M. Amanda, Deniston, Colin, Srinivas, Prathna, Schellenberger, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157762/
https://www.ncbi.nlm.nih.gov/pubmed/24932887
http://dx.doi.org/10.1021/bc500215m

Ejemplares similares

Ejemplares similares