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Maltose-Binding Protein Fusion Allows for High Level Bacterial Expression and Purification of Bioactive Mammalian Cytokine Derivatives

Fusokines are chimeric proteins generated by the physical coupling of cytokines in a single polypeptide, resulting in proteins with highly pleiotropic activity and the potential to treat cancer and autoimmune ailments. For instance, the fusokine GIFT15 (GM-CSF and Interleukin 15 Fusion Transgene) ha...

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Detalles Bibliográficos
Autores principales:	Pennati, Andrea, Deng, Jiusheng, Galipeau, Jacques
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157803/ https://www.ncbi.nlm.nih.gov/pubmed/25198691 http://dx.doi.org/10.1371/journal.pone.0106724

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