Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?

Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology a...

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Autores principales: Reizis, Boris, Colonna, Marco, Trinchieri, Giorgio, Barrat, Franck, Gilliet, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157822/
https://www.ncbi.nlm.nih.gov/pubmed/21779033
http://dx.doi.org/10.1038/nri3027
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author Reizis, Boris
Colonna, Marco
Trinchieri, Giorgio
Barrat, Franck
Gilliet, Michel
author_facet Reizis, Boris
Colonna, Marco
Trinchieri, Giorgio
Barrat, Franck
Gilliet, Michel
author_sort Reizis, Boris
collection PubMed
description Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field to discuss their thoughts on the development and functions of pDCs — do these cells serve mainly as a major source of type I interferons or do they also make other important contributions to immune responses?
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spelling pubmed-41578222014-09-08 Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Reizis, Boris Colonna, Marco Trinchieri, Giorgio Barrat, Franck Gilliet, Michel Nat Rev Immunol Article Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field to discuss their thoughts on the development and functions of pDCs — do these cells serve mainly as a major source of type I interferons or do they also make other important contributions to immune responses? Nature Publishing Group UK 2011-07-22 2011 /pmc/articles/PMC4157822/ /pubmed/21779033 http://dx.doi.org/10.1038/nri3027 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Reizis, Boris
Colonna, Marco
Trinchieri, Giorgio
Barrat, Franck
Gilliet, Michel
Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?
title Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?
title_full Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?
title_fullStr Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?
title_full_unstemmed Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?
title_short Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?
title_sort plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157822/
https://www.ncbi.nlm.nih.gov/pubmed/21779033
http://dx.doi.org/10.1038/nri3027
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