Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs

BACKGROUND: The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cells. Cancers of both lymphoid and non-lymphoid origin also express GzB, and in s...

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Detalles Bibliográficos
Autores principales: Pearson, Joel D, Zhang, Jingxi, Wu, Zuoqiao, Thew, Kayla D, Rowe, Katelynn J, Bacani, Julinor TC, Ingham, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158053/
https://www.ncbi.nlm.nih.gov/pubmed/25168906
http://dx.doi.org/10.1186/1476-4598-13-199

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